Correlation of Fibrinogen Level with PELOD-2 Score As A Predictive Factor For Mortality in Pediatric Sepsis

Dia Tri Susanti; Gema Nazri Yanni; Johannes H. Saing; Erna Mutiara; Aridamuriany D. Lubis; Olga R. Siregar

doi:10.47353/jsocmed.v2i11.106

Correlation of Fibrinogen Level with PELOD-2 Score As A Predictive Factor For Mortality in Pediatric Sepsis

Dia Tri Susanti
Department of Pediatrics, Faculty of Medicine, Universitas Sumatera Utara, Medan, North Sumatra, Indonesia
Gema Nazri Yanni
Department of Pediatrics, Faculty of Medicine, Universitas Sumatera Utara, Medan, North Sumatra, Indonesia
Johannes H. Saing
Department of Pediatrics, Faculty of Medicine, Universitas Sumatera Utara, Medan, North Sumatra, Indonesia
Erna Mutiara
Faculty of Public Health, Universitas Sumatera Utara, Indonesia
Aridamuriany D. Lubis
Department of Pediatrics, Faculty of Medicine, Universitas Sumatera Utara, Medan, North Sumatra, Indonesia
Olga R. Siregar
Department of Pediatrics, Faculty of Medicine, Universitas Sumatera Utara, Medan, North Sumatra, Indonesia

Abstract

Introduction: Fibrinogen is a prognostic biomarker in septic children, lower fibrinogen levels are closely related to higher risk of death. Organ dysfunction was diagnosed based on PELOD-2 score. The aim of this study was to determine the corelation between fibrinogen levels and PELOD-2 score as a predictor of mortality in pediatric patient with sepsis treated in the PICU and HCU at H. Adam Malik General Hospital.

Method: A cross-sectional study of pediatric patients with sepsis treated in the PICU and HCU H. Adam Malik General Hospital, Medan. Correlation of fibrinogen levels with PELOD-2 scores was seen on day I and day III of treatment in patient aged 1 month to 18 years with a hospital stay of at least 72 hours and were analyzed using the Spearman test and the relationship between fibrinogen and mortality was analyzed using the Mann-Whitney test.

Results: 50 subjects were recruited in this study, fibrinogen levels had no correlation with PELOD-2 score day I (p = 0,074, r = -0,225) and with PELOD-2 score days III (p = 0,110, r = -0,229) and with mortality (p = 0,160).

Conclusion: Fibrinogen levels were not correlate with PELOD-2 score as a predictive factor for mortality in septic children.

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Published at

30. November 2023
https://doi.org/10.47353/jsocmed.v2i11.106
Issue:

Vol. 2 No. 11 (2023): November
Section:

Articles
Keywords:

Fibrinogen PELOD-2 score Mortality
References:

Hadinegoro SRS, Chairulfa tah A, Latief A, Pudjiadi AH, Malisie RF, Alam A. Konsensus: Diagnosis dan tatalaksana sepsis pada anak. Jakarta: Ikatan Dokter Anak Indonesia. 2016: 1-6.

Cruz AT, Lane RD, Balamuth F, Aronson PL, Ashby DW, Neuman MI, dkk. Updates on pediatric sepsis. J Am Coll Emerg Physicians Open. 2020: 1-3.

Yanni GN, Saragih RAC. Platelet profile as prognostic factor in critically ill children. Open Access Maced J Med Sci. 2020; 966-8.

Priyatiningsih DR, Latief A, Pudjiadi AH. Karakteristik sepsis di pediatric intensive care unit RSUPN dr. Cipto Mangunkusumo. Jakarta: Fakultas Kedokteran Universitas Indonesia; 2016

Levi M, De Jonge E, Poll T. Rationale for restoration of physiological anticoagulant pathways in patients with sepsis and disseminated intravascular coagulation. Crit Care Med. 2001; 29: 90-4.

Levi M, Schultz M, Poll T. Disseminated intravascular coagulation in infectious disease. Semin Thromb Hemost. 2010; 36: 367-77.

Tang X, Shao L, Dou J, Zhou Y, Chen M, Cui Y, dkk. Fibrinogen as a predictor in pediatric patients with sepsis: A Database Study. Mediators Inflamm. 2020: 1-9.

Matsubara T, Yamakawa K, Umemura Y, Gando S, Ogura H, Shiraishi A, dkk. Significance of plasma fibrinogen level and antithrombin activity in sepsis: A multicenter cohor study using a cubic spline model. Thromb Res. 2019; 181: 17-23.

Pudjiadi MT, Said M, Mangunatmadja I, Satari HI, Wulandari HF, Andriastuti M. Angka Kejadian koagulasi intravaskular diseminata pada pneumonia. Sari Pediatri. 2012; 14: 52 -6.

Azfar M, Khan M, Khurshid M. Fibrinogen at admission is an independent predictor of mortality in severe sepsis and septic shock. Crit Care. 2014; S2-S182.

Sharma A, Sikka M, Gomber S, Sharma S. Plasma fibrinogen and d-dimer in children with sepsis: A Single-centre Experience. Iran J Pathol. 2018; 13: 272-5.

Huisman E, Crighton G. Pediatric fibrinogen part I- pitfalls in fibrinogen evaluation and use of fibrinogen replacement products in children. Frontiers in pediatric. 2021; 9: 1-10.

Omiya K, Sato H, Sato T, Wykes L, Hong M, Hatzakorzian R. Albumin and fbrinogen kinetics in sepsis: a prospective observational study. Omiya et al. Critical Care. 2021; 25: 1-6.

Wada H, Mori Y, Okabayashi K, Gabazza EC, Kushiya F, Watanabe M, dkk. High plasma fibrinogen level is associated with poor clinical outcome in DIC patients. Am J Hematol. 2003; 7: 1-7.

Simanjuntak Y, Saputra I, Triratna S, Bakri A, Iriani Y. Validation of PELOD-2 score as a predictor of life-threatening organ dysfunction in pediatric sepsis. Paediatr Indones. 2020; 60 (5): 227-32.
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Susanti, D. T., Yanni, G. N., Saing, J. H., Mutiara, E., Lubis, A. D., & Siregar, O. R. (2023). Correlation of Fibrinogen Level with PELOD-2 Score As A Predictive Factor For Mortality in Pediatric Sepsis. Journal of Society Medicine, 2(11), 384–391. https://doi.org/10.47353/jsocmed.v2i11.106