The Aryl Hydrocarbon Receptor (AhR) Level Based on Age and Clinical Type of Melasma
Authors
Abstract
Introduction: Melasma is the most common pigmentation condition on the face due to excessive melanin production and release. The main predisposing factor for melasma is UV exposure. Aryl Hydrocarbon Receptor (AhR) is a ligand-dependent transcription factor that regulates the expression of a very large number of target genes in humans. Facial hyperpigmentation is increased in people living in air-polluted areas with particulate matter2.5 (PM2.5) concentrations. Dioxin compounds contained in PM2.5 can activate AhR signaling. This study aims to determine the aryl hydrocarbon receptor (AhR) level based on age and clinical type of melasma.
Methods: This study was an observational study with a cross-sectional design of 30 women with melasma at Prof. CPL Hospital. This study was conducted after obtaining ethical clearance from the Research Ethics Commission of the University of North Sumatra and has obtained permission from the research field of Prof. Chairuddin Panusunan Lubis Hospital. All subjects underwent history taking, physical examination, dermatological examination, and blood sampling to assess AhR levels by ELISA test. Data were analyzed with Chi square test to assess AhR levels based on age, and to assess AhR levels based on clinical type of melasma with Kruskal Wallis test.
Results: This study shows that the majority of melasma age is 41-50 years with the highest mean AhR level is 882,61 ng/mL, while the lowest AhR level is in the age range of 20-30 years with a mean of 271,5 ng/mL. Chi square test showed that there was a significant relationship between AhR levels and age (p < 0,001). The highest mean AhR levels in melasma subjects were centrofacial type with a mean of 795,50 ng/mL, while the lowest mean AhR levels were found in melasma subjects with malar type with a mean of 623,36 ng/mL. The Kruskal Wallis test showed that there was no significant difference in AhR levels based on the clinical type of melasma (p = 0,930).
Conclusion: That increased the age, the highest AhR levels. The highest average AhR level was centrofacial type of melasma. There was no significant difference in AhR levels based on the clinical type of melasma.
Similar Articles
- T. Rifqi Hashmi, Harris Hasan, Hilfan Ade Putra Lubis, The Relationship between LDL/ HDL Ratio and Coronary Lesion Severity Measured by Syntax Score in Patients with Non-Elevation Acute Myocardial Infarction at Hajj Adam Malik General Hospital, Medan , Journal of Society Medicine: Vol. 3 No. 5 (2024): May
- Adityo Prabowo, Use of Chest X-Ray (CXR) in Covid-19 Screening as A Modalities , Journal of Society Medicine: Vol. 1 No. 2 (2022): November
- Roni Abimanyu, Andika Sitepu, Ali Nafiah Nasution, Comparison of Syntax II Score And Grace Score As Predictors of Major Cardiovascular Events 30 Days after Treatment in STEMI Undergoing PPCI , Journal of Society Medicine: Vol. 3 No. 6 (2024): June
- Effi Rohani Nuzul Sari, Aldy Safruddin Rambe, Irina Kemala Nasution, The Relationship between Cognitive Function and Quality of Life in Patient with Intracranial Tumors at Haji Adam Malik Hospital Medan , Journal of Society Medicine: Vol. 2 No. 8 (2023): August
- Muhammad Harmen Reza Siregar, Elvita Rahmi Daulay, Refli Hasan, Role of Chest Radiograph in Diagnosis of Acyanotic Congenital Heart Disease , Journal of Society Medicine: Vol. 1 No. 3 (2022): December
- Annisa Nidya Rahmatika Sitepu, Dharma Lindarto, Melati Silvanni Nasution, Lipid Profile in Confirmed Covid-19 Patients with Type 2 Diabetes Mellitus At Haji Adam Malik General Hospital Medan from March 2020 to December 2021 , Journal of Society Medicine: Vol. 2 No. 3 (2023): March
- Rachmad Try Hendro, Osmond Muftilov Pison, Management of Acute Respiratory Distress Syndrome Due to Transfusion-Related Acute Lung Injury and Pulmonary Contusion in a Patient with Moderate Head Injury Post-Craniotomy Decompression, Epidural Hematoma, and Posterolateral Rib Fractures 2-6 , Journal of Society Medicine: Vol. 4 No. 7 (2025): July
- Suwarman, Tresna Kusumah Natapraja, Management af a Patient with Guillain-Barré Syndrome Miller Fisher Type and Hospital-Acquired Pneumonia in the Intensive Care Unit : a Case Report , Journal of Society Medicine: Vol. 3 No. 11 (2024): November
- Cut Putri Hazlianda, Dina Arwina Dalimunthe, Awalia Astarina, Generalized Exfoliative Dermatitis Suspected Caused by COVID-19 Vaccine : A Case Report , Journal of Society Medicine: Vol. 2 No. 12 (2023): December
- Dian Primadia Putri, Rahmad Isnanta Sembiring, Tambar Kembaren, Putri Eyanoer, Relationship of D-dimer Value to Mortality in Covid-19 Patients with Acute Coronary Syndrome at Haji Adam Malik Hospital Medan , Journal of Society Medicine: Vol. 2 No. 4 (2023): April
<< < 1 2 3 4 5 6 7 8 9 10 > >>
You may also start an advanced similarity search for this article.