Comparative Analysis of Ankle-Brachial Index in Chronic Myeloid Leukemia Patients Treated with Imatinib versus Nilotinib at Adam Malik Hospital
Authors
Abstract
Introduction: Chronic myeloid leukemia (CML) is commonly managed with tyrosine kinase inhibitors (TKIs) such as imatinib and nilotinib. However, these therapies are associated with cardiovascular risks, including peripheral arterial disease (PAD). This study compares the Ankle-Brachial Index (ABI), a non-invasive measure of PAD, in CML patients receiving imatinib or nilotinib at Adam Malik Hospital, Medan.
Methods: A cross-sectional study was conducted from December 2023 to February 2024 at Adam Malik Hospital. Forty-eight CML patients (34 on imatinib, 14 on nilotinib) were enrolled using consecutive sampling. ABI was measured to assess PAD prevalence, with values <0.9 indicating abnormality. Data were analyzed using independent t-tests and chi-square tests, with significance set at p<0.05.
Results: The mean age was 42.9 years (imatinib) and 49.1 years (nilotinib). Abnormal ABI values were observed in 20.6% (7/34) of imatinib-treated patients and 50% (7/14) of nilotinib-treated patients. The mean ABI for the left leg was significantly lower in the nilotinib group (0.91 ± 0.12) compared to the imatinib group (1.06 ± 0.11, p=0.017). A significant difference in ABI values between groups was confirmed (p=0.042, odds ratio 3.857), indicating a higher PAD risk with nilotinib.
Conclusion: Nilotinib therapy is associated with a higher incidence of PAD compared to imatinib in CML patients. These findings underscore the need for routine cardiovascular monitoring in TKI-treated patients and further research into the vascular effects of TKIs.
Similar Articles
- Adi Retno, Evo Elidar Harahap, Bayu Rusfandi Nasution, Relationship between Stage of Chronic Kidney Disease with Cardiomegaly Imaging in Posteroanterior Chest X-Ray at Haji Adam Malik Hospital Medan , Journal of Society Medicine: Vol. 2 No. 8 (2023): August
- Amalia Noor Zafira Nasution, Aldy S Rambe , Haflin Soraya Hutagalung , Relation between Parkinson's Disease Severity and Cognitive Function with Monstreal Cognitive Assessment Indonesia , Journal of Society Medicine: Vol. 2 No. 9 (2023): September
- Marisa Heidiyana, Khairul Putra Surbakti, Haflin Soraya Hutagalung, The Association Between Degree of Severity and Number of Medications with Quality of Life in Parkinson's Disease Patients , Journal of Society Medicine: Vol. 2 No. 4 (2023): April
- Riris Sibarani, Aida Fitri, Haflin Soraya Hutagalung, Association between Clinical Stage of HIV and Peripheral Sensory Neuropathy , Journal of Society Medicine: Vol. 3 No. 1 (2024): January
- Antonius Leonardo Purba, Nizam Zikri Akbar, Yuke Sarastri, The Relationship between Myocardial Strain Using 2D Speckle Tracking Echocardiography and Coronary Lesion Severity Measured by Syntax Score in Patients with Chronic Coronary Syndrome at Haji Adam Malik Hospital , Journal of Society Medicine: Vol. 3 No. 4 (2024): April
- Muhammad Avicienna Zamzami, Elvita Rahmi Daulay, Suzy Indharty, Evan’s Index Values and Its Relationship with Individual Characteristics (Age and Gender) in Head CT-Scan Examination at Haji Adam Malik Hospital Medan 2021-2022 , Journal of Society Medicine: Vol. 2 No. 7 (2023): July
- Rifki Mirza Alfuadi , Anggia Chairuddin Lubis , Yuke Sarastri-Hilfan Ade Putra , The Left Atrioventricular Coupling Index as a Predictor of Major Cardiovascular Events in Chronic Heart Failure Patients at Adam Malik Hospital Medan , Journal of Society Medicine: Vol. 4 No. 6 (2025): June
- Dwi Prianto, Wika Hanida Lubis, Alwi Thamrin Nasution, Correlation Between Depression Level and Red Blood Cell Distribution Width (RDW) and Erythrocyte Sedimentation Rate (ESR) in Chronic Kidney Disease (CKD) Patients Undergoing Regular Hemodialysis at Haji Adam Malik General Hospital Medan , Journal of Society Medicine: Vol. 2 No. 5 (2023): May
- Har Rawishwar Singh Dhilion, Ali Nafiah Nasution, Andika Sitepu, Association between Systemic Inflammatory Immunity Index and Intracoronary Thrombus Burden in Acute Myocardial Infarction with ST Segment Elevation (IMA EST) Patients Undergoing Primary Percutaneous Coronary Intervention at Haji Adam Malik Hospital , Journal of Society Medicine: Vol. 3 No. 2 (2024): February
- Putri Wulandari Harahap, Setia Putra Tarigan, Noni Novisari Soeroso, Taufik Ashar, Effectiveness of Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase Inhibitor (TKI) on Life Expectancy in Non-Small Cell Lung Cancer Patients in Medan City , Journal of Society Medicine: Vol. 4 No. 2 (2025): February
You may also start an advanced similarity search for this article.