The Relationship between Transient Ischemic Dilation (TID) and Severity of Coronary Artery Disease (CAD) in Patients with Chronic Coronary Syndrome (CCS) in Haji Adam Malik Medan, Indonesia

Ratna Mariana Tamba; Hilfan Ade Putra Lubis; Zulfikri Mukhtar; Andika Sitepu; Faisal Habib; Cut Aryfa Andra; T. Bob Haykal

doi:10.47353/jsocmed.v2i9.88

The Relationship between Transient Ischemic Dilation (TID) and Severity of Coronary Artery Disease (CAD) in Patients with Chronic Coronary Syndrome (CCS) in Haji Adam Malik Medan, Indonesia

Ratna Mariana Tamba
Cardiology and Vascular Resident, Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia / Haji Adam Malik General Hospital, Medan, Indonesia
Hilfan Ade Putra Lubis
Cardiologist, Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia / Haji Adam Malik General Hospital, Medan, Indonesia
Zulfikri Mukhtar
Cardiologist, Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia / Haji Adam Malik General Hospital, Medan, Indonesia
Andika Sitepu
Cardiologist, Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia / Haji Adam Malik General Hospital, Medan, Indonesia
Faisal Habib
Cardiologist, Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia / Haji Adam Malik General Hospital, Medan, Indonesia
Cut Aryfa Andra
Cardiologist, Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia / Haji Adam Malik General Hospital, Medan, Indonesia
T. Bob Haykal
Cardiologist, Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia / Haji Adam Malik General Hospital, Medan, Indonesia

Abstract

Introduction: TID ratio derived from ratio of LV volume in stress and rest phase of MPS. It is said that this phenomenon has been a useful marker of severe CAD, that can be present with atypical angina. This occurs due to global myocardial hypoperfusion caused by severe and extensive CAD.

Method: This study was an analytic observational study with a retrospective cohort design in CCS patients who underwent Myocardial Perfusion SPECT at Haji Adam Malik General Hospital from January 2022 to April 2023. All participants underwent MPS with Tc99m sestamibi with pharmacology Adenosine stress test and coronary angiography. The MPS could be performed before or after coronary angiography without any revascularization procedure between the two examination preocedures. An unpaired t-test analysis was performed to find the mean difference in TID values in the mild CAD and moderate-severe CAD groups.

Results: The study subjects totaled 93 people with an average age of 55.87±7.44. It was found that the TID value was significantly different between the two groups of mild and moderate-severe CAD based on Syntax score, 0.906±0.13 vs 1.03±0.11 in the mild vs moderate-severe CAD group (p<0.001). Bivariate analysis showed that in this study, the ratio of TID was only associate with LV ESV and LV EDV in stress phase of MPS (p = 0.001).

Conclusion: There is a relationship between TID and CAD severity based on Syntax score with higher TID values in patients with moderate-severe CAD compared to patients with mild CAD. TID ratio was only depends on severity od CAD and directly proportional to the volume of LV in the stress phase, suitable to the theory that said TID ratio comes from ratio of LV volume in stress and rest phase of MPS.

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Published at

30. September 2023
https://doi.org/10.47353/jsocmed.v2i9.88
Issue:

Vol. 2 No. 9 (2023): September
Section:

Articles
Keywords:

Chronic coronary syndrome Coronary artery disease Severity of CAD Syntax score Transient ischemic dilation
References:

Knuuti J, Wijns A, Saraste A, Capodanno D, Barbato E, Funck-Brentano C, et al. The Task Force for the diagnosis and management of chronic coronary syndromes of the European Society of Cardiology (ESC). 2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes. European Heart Journal. 2020; (41): 436-440.

Neumann FJ, Sousa-Uva M, Ahlsson A, Alfonso F, Banning AP, Benedetto U, et al. The Task Force on myocardial revascularization of the European Society of Cardiology (ESC) and European Association for Cardio-Thoracic Surgery (EACTS). 2018 ESC/EACTS Guidelines on myocardial revascularization. European Heart Journal. 2019; (40): 87–165.

Xu Y, Arsanjani R, Clond M, Hyun M, Lemley M, Fish M, et al. Transient ischemic dilation for coronary artery disease in quantitative analysis of same-day sestamibi myocardial perfusion SPECT. Journal of Nuclear Cardiology. 2012;19(3):465-73.

Abidov A, Bax JJ, Hayes SW, Hachamovitch R, Cohen I, Gerlach J, et al. Transient Ischemic Dilation Ratio of the Left Ventricle is a Significant Predictor of Future Cardiac Events in Patients with otherwise Normal Myocardial Perfusion SPECT. J Am Coll Cardiol 2013; 42:1818-25.

Akgun T, Oduncu V, Bitigen A, Karabay CY, Erkol A, Kocabay G, et al. Baseline SYNTAX Score and Long-Term Outcome in Patients With ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention. Clinical and Applied Thrombosis/Hemostasis 2015; 21(8):712-719.

Perhimpunan Dokter Spesialis Kardiovaskular Indonesia. Pedoman Tatalaksana Panduan Pemilihan Modalitas Diagnostik Non Invasif pada Angina Pektoris Stabil. 2020. Jakarta: Perki.

Dorbala S, Ananthasubramaniam K, Armstrong IS, Chareonthaitawee P, DePuey EG, Einstein AJ, et al. Single Photon Emission Computed Tomography (SPECT) Myocardial Perfusion Imaging Guidelines: Instrumentation, Acquisition, Processing, and Interpretation. ASNC SPECT Imaging Guidelines. J Nucl Cardiol. 2018; 25:1784–1846.

Sianos G, Morel MA, Kappetein AP, Morice MC, Colombo A, Dawkins K, Brand MVD.et al. The SYNTAX Score: an angiographic tool grading the complexity of coronary artery disease. EuroIntervention. 2005;1(2):219- 227.

Duarte PS, Smanio PE, Oliveira CA, Martins LR, Mastrocolla LE, Pereira JC. Clinical Significance of Transient Left Ventricular Dilation Assessed during Myocardial Tc-99m Sestamibi Scintigraphy. Arq Bras Cardiol. 2003; 81: 479-82, 2003.

Ince S, Karacalioglu O, San H, Emer O, Alagoz E, Yildirim E, et al. Angiographic results of the patients with positive transient ischemic dilatation on their gated myocardial perfusion imaging scans. Gulhane Med J. 2018; 60: 37-41.

Chen L, Zhang M, Jiang J, Lei B, Sun X. Coronary microvascular dysfunction: An important interpretation on the clinical significance of transient ischemic dilation of the left ventricle on myocardial perfusion imaging. Journal of X-Ray Science and Technology. 2021; 29: 347–360.

Mazzanti M, Germano G, Kiat H, Kavanagh PB, Alexanderson E, Friedman JD, et al. Identification of severe and extensive coronary artery disease by automatic measurement of transient ischemic dilation of the left ventricle in dual-isotope myocardial perfusion SPECT. J Am Coll Cardiol. 1996; 27:1612–20.

Miller RJH, Hu LH, Gransar H, Betancur J, Eisenberg E, Otaki Y, et al. Transient ischemic dilation and post-stress wall motion abnormality increase risk in patients with less than moderate ischemia: analysis of the REFINE SPECT registry. European Heart Journal-cardiovascular Imaging 2020; 21:567-575.

Liu C-J, Wu Y-W, Ko K-Y, Chen Y-C, Cheng M-F, Yen R-F, et al. Incremental Diagnostic Performance of Combined Parameters in the Detection of Severe Coronary Artery Disease Using Exercise Gated Myocardial Perfusion Imaging. PLoS ONE. 2015; 10(7): e0134485.

Taillefer R. Transient dilation of the left ventricular cavity observed during myocardial perfusion imaging: What is its incremental diagnostic value. J Nucl Cardiol. 2018; 25:593–5.
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Tamba, R. M., Lubis, H. A. P., Mukhtar, Z., Sitepu, A., Habib, F., Andra, C. A., & Haykal, T. B. (2023). The Relationship between Transient Ischemic Dilation (TID) and Severity of Coronary Artery Disease (CAD) in Patients with Chronic Coronary Syndrome (CCS) in Haji Adam Malik Medan, Indonesia. Journal of Society Medicine, 2(9), 307–313. https://doi.org/10.47353/jsocmed.v2i9.88