The Role of Herbal Medicine for Hypertrophic Scars Management

Ira Mendrofa; Imam Budi Putra

doi:10.71197/jsocmed.v4i1.191

The Role of Herbal Medicine for Hypertrophic Scars Management

Ira Mendrofa
Dermatology and Venereology Department, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia
Imam Budi Putra
Dermatology and Venereology Department, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia

Abstract

The process of wound healing is intricate, involving highly coordinated and synchronized mechanisms. Deviations from normal physiological responses can result in hypertrophic scarring. In recent years, there has been a global resurgence of interest in herbal remedies. Many plant-derived compounds and extracts have demonstrated the capacity to inhibit hypertrophic scar formation. The primary mode of action involves inhibiting proliferation and/or triggering apoptosis in scar fibroblasts by modulating various pathways, including PI3K/AKT, VEGF, and TGF-Beta/SMAD. Advancing our comprehension of hypertrophic scar pathophysiology, conducting follow-up research, and pursuing future investigations will help overcome current challenges and lead to the development of promising therapeutic approaches.

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Published at

31. January 2025
https://doi.org/10.71197/jsocmed.v4i1.191
Issue:

Vol. 4 No. 1 (2025): January
Section:

Articles
Keywords:

Herbal medicine Hypertrophic scars Wound healing
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Mendrofa, I., & Putra, I. B. (2025). The Role of Herbal Medicine for Hypertrophic Scars Management. Journal of Society Medicine, 4(1), 28–33. https://doi.org/10.71197/jsocmed.v4i1.191