The Role of Herbal Medicine for Hypertrophic Scars Management

Ira Mendrofa; Imam Budi Putra

doi:10.71197/jsocmed.v4i1.191

The Role of Herbal Medicine for Hypertrophic Scars Management

Ira Mendrofa
Dermatology and Venereology Department, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia
Imam Budi Putra
Dermatology and Venereology Department, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia

Abstract

The process of wound healing is intricate, involving highly coordinated and synchronized mechanisms. Deviations from normal physiological responses can result in hypertrophic scarring. In recent years, there has been a global resurgence of interest in herbal remedies. Many plant-derived compounds and extracts have demonstrated the capacity to inhibit hypertrophic scar formation. The primary mode of action involves inhibiting proliferation and/or triggering apoptosis in scar fibroblasts by modulating various pathways, including PI3K/AKT, VEGF, and TGF-Beta/SMAD. Advancing our comprehension of hypertrophic scar pathophysiology, conducting follow-up research, and pursuing future investigations will help overcome current challenges and lead to the development of promising therapeutic approaches.

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Published at

31. January 2025
https://doi.org/10.71197/jsocmed.v4i1.191
Issue:

Vol. 4 No. 1 (2025): January
Section:

Articles
Keywords:

Herbal medicine Hypertrophic scars Wound healing
References:

Bran GM, Goessler UR, Hormann K, Riedel F, Sadick H. Keloids: Current concepts of pathogenesis (Review). Int J Mol Med. 2009;24:283-93.

Saddawi-Konefka R, Watson D. Nonsurgical Treatment of Keloids and Hypertrophic Scars. Facial Plast Surg. 2019;35(3):260–6.

Berman B, Maderal A, Raphael B. Keloids and hypertrophic scars: Pathophysiology, classification, and treatment. Dermatol Surg. 2017;43:S3–18.

Kouotou EA, Nansseu JR, Omona Guissana E, Mendouga Menye CR, Akpadjan F, Tounkara TM, et al. Epidemiology and clinical features of keloids in Black Africans: a nested case–control study from Yaoundé, Cameroon. Int J Dermatol. 2019;58(10):1135–40.

Song Y, Wang T, Yang L, Wu J, Chen L, Fan X, et al. EGCG inhibits hypertrophic scar formation in a rabbit ear model. J Cosmet Dermatol. 2022;1–10.

Ye Q, Wang SJ, Chen JY, Rahman K, Xin HL, Zhang H. Medicinal plants for the treatment of hypertrophic scars. Evid Based Complement Altern Med. 2015;2015:1–16.

Lv K, Xia Z. Chinese expert consensus on clinical prevention and treatment of scar. Burn Trauma. 2018;6:1–9.

Sidgwick GP, McGeorge D, Bayat A. A comprehensive evidence-based review on the role of topicals and dressings in the management of skin scarring. Arch Dermatol Res. 2015;307(6):461–77.

Bylka W, Znajdek-Awizeń P, Studzińska-Sroka E, Dańczak-Pazdrowska A, Brzezińska M. Centella asiatica in dermatology: An overview. Phyther Res. 2014;28(8):1117–24.

Sun B, Wu L, Wu Y, Zhang C, Qin L, Hayashi M, et al. Therapeutic Potential of Centella asiatica and Its Triterpenes: A Review. Front Pharmacol. 2020;11:1–24.

Gohil KJ, Patel JA, Gaijar AK. Pharmacological review on Centella asiatica: A potential herbal cure-all. Indian J Pharm Sci. 2010;72(5):546–56.

Wollina U, Abdel-Naser MB, Mani R. A review of the microcirculation in skin in patients with chronic venous insufficiency: the problem and the evidence available for therapeutic options. Int J Low Extrem Wounds. 2006;5(3):169-80.

Tang B, Zhu B, Liang Y, Bi L, Hu Z, Chen B, Zhang K, Zhu J. Asiaticoside suppresses collagen expression and TGF-β/Smad signaling through inducing Smad7 and inhibiting TGF-βRI and TGF-βRII in keloid fibroblasts. Arch Dermatol Res. 2011;303:563-72.

Song J, Xu H, Lu Q, Xu Z, Bian D, Xia Y, Wei Z, Gong Z, Dai Y. Medcassoside suppresses migration of fibroblasts from keloids: involvement of p38 kinase and PI3K signaling pathways. Burns. 2012;38:677-84.

Ago MBN, Adifa DP. Benefits of Gotu Kola Leaf in Responding to Prevent The Form of Keloid in The Wound. Indones J Glob Health Res. 2020;2(1):23-8.

Howell N, Krings A, Braham R. Guide to the littoral zone vascular flora of Carolina bay lakes (U.S.A.). Biodivers Data J. 2016.

Pazyar N, Feily A. Garlic in dermatology. Dermatol Rep. 2011;3:e4.

Feily A, Namazi MR, Pazyar N, Saboktakin M, Saboktakin M. Garlic Extract as a Novel Addition to Antikeloid Armamentarium: An Untested Hypothesis. J Altern Complement Med. 2009;15(11):1153-4.

Shedoeva A, Leavesley D, Upton Z, Fan C. Wound healing and the use of medicinal plants. Evid Based Complement Altern Med. 2019;2019:1–31.

Kamath M. Pharmacokinetics of Curcumin: Problems and Promises. World J Pharm Res. 2020;9(5):2043–9.

Mehta M, Branford OA, Rolfe KJ. The evidence for natural therapeutics as potential anti-scarring agents in burn-related scarring. Burn Trauma. 2016;4(1):1–12.

Heppt MV, Breuninger H, Reinholz M, Feller-Heppt G, Ruzicka T, Gauglitz GG. Current strategies in the treatment of scars and keloids. Facial Plast Surg. 2015;31(4):386–95.

Gold MH, Berman B, Clementoni MT, Gauglitz GG, Nahai F, Murcia C. Updated international clinical recommendations on scar management: Part 1 - Evaluating the evidence. Dermatol Surg. 2014;40(8):817–24.

Grigoryan KV, Kampp JT. Summary and evidence grading of over-the-counter scar treatments. Int J Dermatol. 2020;59(9):1136–43.

Jenwitheesuk K, Surakunprapha P, Jenwitheesuk K, Kuptarnond C, Prathanee S, Intanoo W. Role of silicone derivative plus onion extract gel in presternal hypertrophic scar protection: A prospective randomized, double-blinded, controlled trial. Int Wound J. 2012;9(4):397–402.

Lingzhi Z, Meirong L, Xiaobing F. Biological approaches for hypertrophic scars. Int Wound J. 2020;17(2):405–18.

Khansa I, Harrison B, Janis JE. Evidence-based scar management: How to improve results with technique and technology. Plast Reconstr Surg. 2016;138(3):165S-178S.

Putra IB, Soebono H, Hadisahputra S, Bachtiar A. The Effect of Roselle (Hibiscus sabdariffa L.) Flowers Extract on the Apoptosis of Fibroblast Proliferation in Keloids. Maced J Med Sci. 2020;8(A):611-614.

He X, Bai Y, Zhao Z, Wang X, et al. Local and traditional uses, phytochemistry, and pharmacology of Sophora japonica L.: A review. J Ethnopharmacol. 2016.

Chen XH, Sun RS, Hu JM, et al. Attenuation of bleomycin-induced lung fibrosis by oxymatrine is associated with regulation of fibroblast proliferation and collagen production in primary culture. Basic Clin Pharmacol Toxicol. 2008;103:278–86.

Fan DL, Zhao WJ, Wang YX, Han SY, Guo S. Oxymatrine inhibits collagen synthesis in keloid fibroblasts via inhibition of transforming growth factor-β1/Smad signaling pathway. Int J Dermatol. 2012;51:463-72.

Qun WJ, Jiu NX. Effect of oxymatrine on cell proliferation, apoptosis, cell cycle and erk1 expression of the fibroblasts derived from hypertrophic scar and keloids. Chin J Minim Invasive Surg. 2011;11(2):259–63.

Shao ZM, Shen ZZ, Fontana JA, Barsky SH. Genistein’s “ER-dependent and independent” actions are mediated through ER pathways in ER-positive breast carcinoma cell lines. Anticancer Res. 2000;20:2409–16.

Theodorescu D, Laderoute KR, Calaoagan JM, Gulding KM. Inhibition of human bladder cancer cell motility by genistein is dependent on epidermal growth factor receptor but not p21ras gene expression. Int J Cancer. 1998;78:775–82.

Davis JN, Kucuk O, Sarkar FH. Genistein inhibits NF-kappa B activation in prostate cancer cells. Nutr Cancer. 1999;35:167–74.

Cao C, Li SR, Dai X, et al. Genistein inhibits proliferation and functions of hypertrophic scar fibroblasts. Burns. 2009;35(1):89–97.

Ye Q, Wang SJ, Chen JY, Rahman K, Xin HL, Zhang H. Medicinal plants for the treatment of hypertrophic scars. Hindawi Evid Based Complement Altern Med. 2015;1–15.
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Mendrofa, I., & Putra, I. B. (2025). The Role of Herbal Medicine for Hypertrophic Scars Management. Journal of Society Medicine, 4(1), 28–33. https://doi.org/10.71197/jsocmed.v4i1.191