Autoimmune Blistering Disease in Children

Cut Putri Hazlianda; Ade Gustina Siahaan

doi:10.47353/jsocmed.v2i11.100

Autoimmune Blistering Disease in Children

Cut Putri Hazlianda
Departemen Dermatologi Venereologi dan Estetika, Fakultas Kedokteran, Universitas Sumatera Utara, Medan, Indonesia
Ade Gustina Siahaan
Departemen Dermatologi Venereologi dan Estetika, Fakultas Kedokteran, Universitas Sumatera Utara, Medan, Indonesia

Abstract

The skin is a particular organ that shields the body from physical stress and other external stresses. There are three layers of skin: epidermis, dermis, and subcutis. The three layers act as interrelated units in carrying out the above functions. One of the skin diseases that can be found is an autoimmune blister or bullous disease that can affect children. Autoimmune bullous or blisters are rare in children, but their quality of life is compromised if they suffer from this disease. Included in autoimmune bullous diseases in children are Linear Immunoglobulin A Bullous Dermatosis (LABD), Dermatitis Herpetiformis (DH), Pemphigus Vulgaris (PV), Pemphigus Foliaceus (PF), Paraneoplastic Pemphigus (PNP), Bullous Pemphigoid (BP), Mucous Membrane (cicatricial) Pemphigoid (MMP), Epidermolysis Bullosa Acquisita (EBA). Diagnosing and treating patients with autoimmune bullous diseases is challenging for clinicians. The skin of infants and children is anatomically thinner than adults, so they are more prone to develop bullae when traumatized.

Similar Articles

Ridho Kurnia Indra, Andre Pasha Ketaren, Hilfan Ade Putra, Correlation Between Pursuit Score And Severity Of Coronary Artery Lesion Assessed by Syntax Score Among Non-ST-Segment Elevation Myocardial Infarction (NSTEMI) Patients in Adam Malik Hospital Medan , Journal of Society Medicine: Vol. 2 No. 8 (2023): August
Cut Putri Hazlianda, Ika Diamanda, Current Pathogenesis and Treatment of Cutaneous Lupus Erythematosus , Journal of Society Medicine: Vol. 2 No. 12 (2023): December
Dian Primadia Putri, Rahmad Isnanta Sembiring, Tambar Kembaren, Putri Eyanoer, Relationship of D-dimer Value to Mortality in Covid-19 Patients with Acute Coronary Syndrome at Haji Adam Malik Hospital Medan , Journal of Society Medicine: Vol. 2 No. 4 (2023): April
Riris Sibarani, Aida Fitri, Haflin Soraya Hutagalung, Association between Clinical Stage of HIV and Peripheral Sensory Neuropathy , Journal of Society Medicine: Vol. 3 No. 1 (2024): January
Ade Irma, Elvita Rahmi Daulay, Anggia Chairuddin Lubis, Measurement of Thoracic Aortic Diameter Using Contrast-Enhanced CT Chest Based on Age, Gender, and Hypertension , Journal of Society Medicine: Vol. 2 No. 3 (2023): March
Cindy Giovanni, Nurita Dian Kestriani Saragi Sitio, Role of Intravenous Immunoglobulin (IVIG) in Patients with Guillain Barre Syndrome with Severe Community Pneumonia in The Intensive Care Unit (ICU) , Journal of Society Medicine: Vol. 3 No. 3 (2024): March
Jessica Patricia Pangaribuan, Santi Syafril, Dian Anindita Lubis, Rahmad Isnanta, Imelda Rey, Effect of Glycemic Parameters on Mortality of Type 2 Diabetes Mellitus Patients with COVID-19 Infection in Haji Adam Malik Hospital Medan , Journal of Society Medicine: Vol. 2 No. 8 (2023): August
Roni Abimanyu, Andre Pasha Ketaren, Ali Nafiah Nasution, Relationship Between Left Atrium Reservoir Strain and One-Year Mortality After Surgery in Patients with Severe Primary Mitral Regurgitation Undergoing Mitral Valve Replacement at Haji Adam Malik General Hospital, Medan , Journal of Society Medicine: Vol. 4 No. 2 (2025): February
Grace Nikensari, Ali Nafiah Nasution, Abdullah Afif Siregar, Monocyte to High-Density Lipoprotein Ratio (MHR) as A Predictor of Major Cardiovascular Events in Acute Myocardial Infarction Patients with ST-Segment Elevation in Patients Undergoing Primary Percutaneous Coronary Intervention at Haji Adam Malik Central General Hospital , Journal of Society Medicine: Vol. 3 No. 5 (2024): May
Radian Ahmad Halimi, Ardi Zulfariansyah, Post-Operative Management for Craniotomy Decompression in Cerebral Edema Patients Due to Cerebral Infarction in The Right Carotic System which Occurred Cerebral Vasospasm , Journal of Society Medicine: Vol. 3 No. 4 (2024): April

<< < 1 2 3 4 5 6 7 > >>

You may also start an advanced similarity search for this article.

PDF

Published at

30. November 2023
https://doi.org/10.47353/jsocmed.v2i11.100
Issue:

Vol. 2 No. 11 (2023): November
Section:

Articles
Keywords:

Autoimmune Blistering Disease Autoimmune Bullous Disease Children
References:

James WD, Elston DM, McMahon PJ. Andrews’ Diseases of the Skin Clinical Atlas. Philadelphia: Elsevier. 2018. p. 1-10 3.

Kubo A, Amagai M. Skin Barrier. In: Sewon K, Masayuki A, Anna LB, et al. Fitzpatrick Dermatology 9th Edition. New York: The McGraw Hill Education. 2019. p. 206-231

Amy K. Forrestel & Robert G. Micheletti. Skin Manifestations of Internal Organ Disorders. In : Kang S, Amagai M, Bruckner AL, Enk AH, Margolis DJ, McMichael AJ, Orringer JS. Fitzpatrick’s Dermatology 9th Edition. New York: McGraw-Hill Education. 2019: p.2425-2440.

Sampaio AL, Aline LB, Barbara NV, Alexandre CG. Skin manifestations associated with systemic diseases --- Part I. A Bras Dermatol. 2021. 96: p.655-671. DOI: https://doi.org/10.1016/j.abd.2021.02.008

Schultz B and Hook K. Bullous diseases in children: a review of clinical features and treatment options. Pediatric Drugs 2019; 21(5): 345-356. DOI: https://doi.org/10.1007/s40272-019-00349-3

Pradhan S, Jha K, Kumari P, Shrestha S, Jha AK. Chronic Bullous Disease of Childhood: A Case Report and Review of Literature of Bullous Diseases in Children. Nepal Journal of Dermatology, Venereology & Leprology 2022; 20(2): 69-75. DOI: https://doi.org/10.3126/njdvl.v20i2.47326

Mellyanawati. Laporan kasus: seorang anak dengan penyakit bula diduga Chronic Bullous Disease of Childhood. Jurnal Ilmiah Kedokteran Wijaya Kusuma 2021; 10 (2): 176-18

Bruckner AL. Inherited and Acquired Blistering Diseases. Neonatal and Infant Dermatology 3rd edition. Elsevier Saunders, USA. 2015. p: 151–154.

Oentari W, Mahadi IDR, Nababan KA. 2020. Kesulitan Diagnosis Penyakit Bulosa Pada Anak. MDVI 2020; 47 (3): 127-131.

Fortuna G and Marinkovich (MP). Linear immunoglobulin A bullous dermatosis. Clinics in dermatology 2012; 30(1): 38-50. DOI:10.1016/j.clindermatol.2011.03.008

Reunala T, Hervonen K, and Salmi T. Dermatitis herpetiformis: an update on diagnosis and management. American Journal of Clinical Dermatology 2021; 22(3): 329-338. DOI: https://doi.org/10.1007/s40257-020-00584-2

Salmi T and Hervonen K. Current concepts of dermatitis herpetiformis. Acta dermato-venereologica 2020; 100: 115-121. DOI: 10.2340/00015555-3401

Zingone F, Maimaris S, Auricchio R, Caio GPI, Carroccio A, Elli L, Galliani E., et al. Guidelines of the Italian Societies of Gastroenterology on the diagnosis and management of coeliac disease and dermatitis herpetiformis. Digestive and Liver Disease 2022; 54(10): 1304-1319. DOI: https://doi.org/10.1016/j.dld.2022.06.023

Cardones ARG and Hall RP. Pathophysiology of dermatitis herpetiformis: a model for cutaneous manifestations of gastrointestinal inflammation. Immunology and Allergy Clinics 2012; 32(2): 263-274. doi: 10.1016/j.iac.2012.04.006

Costan VL, Popa C, Hancu MF, Andrese EP, Toader MP. A comprehensive review of the pathophysiology, clinical variants, and management of pemphigus. Experimental and Therapeutic Medicine 2021; 22(5): 1-13. DOI:10.3892/etm.2021.10770

Lambogliaa ALC, Gubitosi AM, Bakerdijan CG, Larraz GG. Pemphigus vulgaris in pediatrics: a case report. Rev Chil Pediatr 2018; 89 (5): 650-654. DOI: 10.4067/S0370-41062018005000708

Didona D, Maglie R, Eming R, and Hertl M. Pemphigus: Current and future therapeutic strategies. Front Immunol 2019; 10: 1418. DOI: 10.3389/fimmu.2019.01418

Amber KT, Valdebran M and Grando SA. Nondesmoglein anti bodies in patients with pemphigus vulgaris. Front Immunol 2018; 9: 1190. DOI: 10.3389/fimmu.2018.01190

Evans MS, Culton DA, Diaz LA, George PB, Morrel DS. Childhood pemphigus foliaceus presenting as a polycyclic eruption: Case report and review of the literature. Pediatric Dermatology 2019; 36(2): 236-241. DOI: 10.1111/pde.13750

Stanley JR. The pathophysiology of pemphigus. Journal of Dermatological Science 2000; 24: 155-157

Grace MY MY, Chow JS, and Taylor GA. Review of paraneoplastic syndromes in children. Pediatric Radiology 2019; 49: 534-550. DOI: https://doi.org/10.1007/s00247-019-04371-y

Maruta CW, Miyamoto D, Aoki V, Carvalho RGR, Cunha BM, Santi CG. Paraneoplastic pemphigus: a clinical, laboratory, and therapeutic overview. Anais brasileiros de dermatologia 2019; 94: 388-398. DOI: http://dx.doi.org/10.1590/abd1806-4841.20199165

Czernik A, Camilleri M, Pittelkow MR, Grando SA. Paraneoplastic autoimmune multiorgan syndrome: 20 years after. Int J Dermatol 2011; 50: 905-14. DOI: https://doi.org/10.1111/j.1365-4632.2011.04868.x

Yong AA and Tey HL. Paraneoplastic pemphigus. Australas J Dermatol 2013; 54: 241-50. DOI: https://doi.org/10.1111/j.1440-0960.2012.00921.x

Ishii N, Teye K, Fukuda S, Uehara R, Hachiya T, Koga H., et al. Anti-desmocollin autoantibodies in nonclassical pemphigus. Br J Dermatol 2015; 173: 59-68. DOI: https://doi.org/10.1111/bjd.13711

Dias DRK, Ramos AF, Yamashita ME, Carcano CBM. Paraneoplastic pemphigus associated with chronic lymphocytic leukemia: a case report. Journal of Medical Case Reports 2018; 12(252): 1-4. DOI: https://doi.org/10.1186/s13256-018-1742-8

Kasperkiewicz M and Zillikens D. The pathophysiology of bullous pemphigoid. Clinical reviews in allergy & immunology 2007; 33: 67-77. DOI: 10.1007/s12016-007-0030-y

Veljic MG, Nikolic M, and Medenica L. Juvenile bullous pemphigoid: the presentation and follow‐up of six cases. Journal of the European Academy of Dermatology and Venereology 2010; 24: 69-72. DOI: 10.1111/j.1468-3083.2009.03264.x

Schmidt E and Zillikens D. Pemphigoid diseases. The Lancet 2013; 381: 320-332. DOI: http://dx.doi.org/10.1016/

Hignett E and Sami N. Pediatric epidermolysis bullosa acquisita: A review. Pediatric Dermatology 2021; 38: 1047-1050. DOI: 10.1111/pde.14722

Santi CG, Gripp AC, Roselino AM, Mello DS, Gordilho JO, Parsillac PF., et al. Consensus on the treatment of autoimmune bullous dermatoses: bullous pemphigoid, mucous membrane pemphigoid, and epidermolysis bullosa acquisita-Brazilian Society of Dermatology. Anais brasileiros de dermatologia 2019; 94: 33-47. doi: http://dx.doi.org/10.1590/abd1806-4841.2019940207

Vorobyev A, Ludwig RJ, and Schmidt E. Clinical features and diagnosis of epidermolysis bullosa acquisita. Expert review of clinical immunology 2017; 13(2): 157-169. DOI: http://dx.doi.org/10.1080/1744666X.2016.1221343

Hübner F, Konig IR, Holtsche MM, Zillikens D, Linder R, Schmidt E. Prevalence and age distribution of pemphigus and pemphigoid diseases among pediatric patients in Germany. Journal of the European Academy of Dermatology and Venereology 2020; 34(11): 2600-2605. DOI: 10.1111/jdv.16467
Share:

Z

Hazlianda, C. P., & Siahaan, A. G. (2023). Autoimmune Blistering Disease in Children. Journal of Society Medicine, 2(11), 366–376. https://doi.org/10.47353/jsocmed.v2i11.100