High Density Lipoprotein (HDL) Level and Blood Urea Nitrogen (BUN)/Creatinin Ratio Relationship with One-Month Outcome in Acute Ischemic Stroke Patients
Authors
Abstract
Introduction: Stroke has caused around 15.5% of all deaths. Evaluation of factors that worsen clinical outcomes is necessary to avoid complications such as renal dysfunction and secondary dyslipidaemia. This study aims to determine the relationship between increasing serum HDL levels and blood urea nitrogen–serum creatinine ratio (BUN/Cr) on clinical outcomes of acute ischemic stroke.
Method: Prospective cohort study was used with subjects being first-onset acute ischemic stroke patients. Demographic, clinical data, and assessment of BUN/Cr and HDL ratios were collected. Subjects were divided into good clinical outcome (mRS 0-2) and poor clinical outcome (mRS 3-6) groups, and then analysed using multiple linear regression multivariate analysis with confidence interval of 95%.
Results: 60 participants met the inclusion criteria. There was a significant relationship between serum BCR levels and poor clinical outcomes (p <0.001) relationship between serum HDL levels and poor clinical outcomes also shown significances (p <0.001) Mean BCR in good and poor clinical outcomes of acute ischemic stroke were (17.08±30.13) and (29.35±67.30) respectively. Mean HDL in good and poor clinical outcomes were (39± 62) and (41 ± 92) respectively. A multiple linear regression analysis showed a positive correlation (p <0.001) between increasing Serum HDL levels and Bun/Cr ratio simultaneously to poor clinical outcomes in acute ischemic stroke patients. The Cut-off point was 20.9 for BUN to creatinine ratio and 46 mg/dL at serum HDL. Both of BUN/Cr ratio and HDL were shown high specificity and could be used as predictors of clinical outcome in acute ischemic stroke patients.
Conclusion: Increased BUN/Cr ratio and increased serum HDL levels were associated with clinical outcomes in patients with acute ischemic stroke.
Similar Articles
- Mufti Muhammad, Netty DL, Chairil AB, Relationship between Hypertension and Aorta Arch Calcification on Chest X-Ray Photos of Ischemic Stroke Patients at The General Hospital Haji Adam Malik Medan 2022 , Journal of Society Medicine: Vol. 2 No. 9 (2023): September
- Rendi Sidiq, Bastian Lubis, Yutu Solihat, Comparison of Pre-Loading Fluid With Norepinephrine Toward Mean Arterial Pressure (MAP) In Sepsis Patients In Intensive Care Unit (ICU) of Haji Adam Malik General Hospital, Medan , Journal of Society Medicine: Vol. 1 No. 2 (2022): November
- Radian Ahmad Halimi, Ardi Zulfariansyah, Post-Operative Management for Craniotomy Decompression in Cerebral Edema Patients Due to Cerebral Infarction in The Right Carotic System which Occurred Cerebral Vasospasm , Journal of Society Medicine: Vol. 3 No. 4 (2024): April
- Annisa Nidya Rahmatika Sitepu, Dharma Lindarto, Melati Silvanni Nasution, Lipid Profile in Confirmed Covid-19 Patients with Type 2 Diabetes Mellitus At Haji Adam Malik General Hospital Medan from March 2020 to December 2021 , Journal of Society Medicine: Vol. 2 No. 3 (2023): March
- Mukhamad Faried, Franciscus Ginting, Tambar Kembaren, Putri Chairani Eyanoer, Factor Influencing Mortality in Moderate - Severe Covid-19 Patients In Tertiary Hospital, Indonesia , Journal of Society Medicine: Vol. 2 No. 7 (2023): July
- Monica Tampubolon, Kiki M. Iqbal, R. A. Dwi Pujiastuti, Osmolarity Changes after Mannitol Administration in Cerebral Edema Patients , Journal of Society Medicine: Vol. 2 No. 7 (2023): July
- Jessica Patricia Pangaribuan, Santi Syafril, Dian Anindita Lubis, Rahmad Isnanta, Imelda Rey, Effect of Glycemic Parameters on Mortality of Type 2 Diabetes Mellitus Patients with COVID-19 Infection in Haji Adam Malik Hospital Medan , Journal of Society Medicine: Vol. 2 No. 8 (2023): August
- Clarisa Monica, Taufik Sungkar, Ilhamd, Correlation between Helicobacter Pylori Caga Antibody Serum and Gastric Premalignant Lesions in Helicobacter Pylori Patients , Journal of Society Medicine: Vol. 2 No. 10 (2023): October
- Bastian Lubis, Putri Amelia, Muhammad Akil, Vincent Viandy, Ade Winata, Yohanes WH George, Early Continuous Renal Replacement Therapy In Patients With St-Elevation Myocardial Infarction And Covid-19 After Percutaneous Coronary Intervention: A Case Report , Journal of Society Medicine: Vol. 1 No. 2 (2022): November
You may also start an advanced similarity search for this article.