The Role of Herbal Medicine for Hypertrophic Scars Management

Ira Mendrofa; Imam Budi Putra

doi:10.71197/jsocmed.v4i1.191

The Role of Herbal Medicine for Hypertrophic Scars Management

Ira Mendrofa
Dermatology and Venereology Department, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia
Imam Budi Putra
Dermatology and Venereology Department, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia

Abstract

The process of wound healing is intricate, involving highly coordinated and synchronized mechanisms. Deviations from normal physiological responses can result in hypertrophic scarring. In recent years, there has been a global resurgence of interest in herbal remedies. Many plant-derived compounds and extracts have demonstrated the capacity to inhibit hypertrophic scar formation. The primary mode of action involves inhibiting proliferation and/or triggering apoptosis in scar fibroblasts by modulating various pathways, including PI3K/AKT, VEGF, and TGF-Beta/SMAD. Advancing our comprehension of hypertrophic scar pathophysiology, conducting follow-up research, and pursuing future investigations will help overcome current challenges and lead to the development of promising therapeutic approaches.

Similar Articles

Effi Rohani Nuzul Sari, Aldy Safruddin Rambe, Irina Kemala Nasution, The Relationship between Cognitive Function and Quality of Life in Patient with Intracranial Tumors at Haji Adam Malik Hospital Medan , Journal of Society Medicine: Vol. 2 No. 8 (2023): August
Marisa Heidiyana, Khairul Putra Surbakti, Haflin Soraya Hutagalung, The Association Between Degree of Severity and Number of Medications with Quality of Life in Parkinson's Disease Patients , Journal of Society Medicine: Vol. 2 No. 4 (2023): April
Aulia Iqbal, Dadik Wahyu Wijaya, Bastian Lubis, Perioperative Nutritional Status of Digestive Surgery Laparotomy Surgery , Journal of Society Medicine: Vol. 1 No. 3 (2022): December
Amalia Noor Zafira Nasution, Aldy S Rambe , Haflin Soraya Hutagalung , Relation between Parkinson's Disease Severity and Cognitive Function with Monstreal Cognitive Assessment Indonesia , Journal of Society Medicine: Vol. 2 No. 9 (2023): September
Ilham Kurniawan Ritonga, Irina Kemala Nasution, Kiki Muhammad Iqbal, Correlation between Tumor Location and Size in Intracranial Tumor Patients and Seizure Types , Journal of Society Medicine: Vol. 3 No. 7 (2024): July
T. Abdul Karim, Dadik Wahyu Wijaya, Rr Sinta Irina, Relationship Blood Gas Analysis And Hemostasis Physics In Multiple Trauma Patients In Adam Malik Hospital Medan , Journal of Society Medicine: Vol. 2 No. 1 (2023): January
Utama Hadiputra Surbakti, R.A. Dwi Pujiastuti, Kiking Ritarwan, Associations between Depression and Anxiety with Sleep Quality in Post Stroke Patients , Journal of Society Medicine: Vol. 2 No. 3 (2023): March
Maulana Taufik, Dadik Wahyu Wijaya, Andriamuri Primaputra Lubis, The Relationship Between The Characteristics of COVID-19 Patients To Predict Mortality in The COVID-19 ICU Special Care , Journal of Society Medicine: Vol. 1 No. 3 (2022): December
Adhika Syaputra, Dadik Wahyu Wijaya, Achsanuddin Hanafie, Patterns of Antibiotic Use in The One Hour Bundle Treatment of Sepsis , Journal of Society Medicine: Vol. 1 No. 3 (2022): December
Sofi Oktaviera Sinaga, Kiking Ritarwan, Kiki Mohammad Iqbal, Relationship between Cluster of Differentiation 4 Levels and Neuroopthalmic Manifestations in HIV Patients in Haji Adam Malik General Hospital Medan , Journal of Society Medicine: Vol. 2 No. 11 (2023): November

<< < 3 4 5 6 7 8 9 10 11 12 > >>

You may also start an advanced similarity search for this article.

PDF

Published at

31. January 2025
https://doi.org/10.71197/jsocmed.v4i1.191
Issue:

Vol. 4 No. 1 (2025): January
Section:

Articles
Keywords:

Herbal medicine Hypertrophic scars Wound healing
References:

Bran GM, Goessler UR, Hormann K, Riedel F, Sadick H. Keloids: Current concepts of pathogenesis (Review). Int J Mol Med. 2009;24:283-93.

Saddawi-Konefka R, Watson D. Nonsurgical Treatment of Keloids and Hypertrophic Scars. Facial Plast Surg. 2019;35(3):260–6.

Berman B, Maderal A, Raphael B. Keloids and hypertrophic scars: Pathophysiology, classification, and treatment. Dermatol Surg. 2017;43:S3–18.

Kouotou EA, Nansseu JR, Omona Guissana E, Mendouga Menye CR, Akpadjan F, Tounkara TM, et al. Epidemiology and clinical features of keloids in Black Africans: a nested case–control study from Yaoundé, Cameroon. Int J Dermatol. 2019;58(10):1135–40.

Song Y, Wang T, Yang L, Wu J, Chen L, Fan X, et al. EGCG inhibits hypertrophic scar formation in a rabbit ear model. J Cosmet Dermatol. 2022;1–10.

Ye Q, Wang SJ, Chen JY, Rahman K, Xin HL, Zhang H. Medicinal plants for the treatment of hypertrophic scars. Evid Based Complement Altern Med. 2015;2015:1–16.

Lv K, Xia Z. Chinese expert consensus on clinical prevention and treatment of scar. Burn Trauma. 2018;6:1–9.

Sidgwick GP, McGeorge D, Bayat A. A comprehensive evidence-based review on the role of topicals and dressings in the management of skin scarring. Arch Dermatol Res. 2015;307(6):461–77.

Bylka W, Znajdek-Awizeń P, Studzińska-Sroka E, Dańczak-Pazdrowska A, Brzezińska M. Centella asiatica in dermatology: An overview. Phyther Res. 2014;28(8):1117–24.

Sun B, Wu L, Wu Y, Zhang C, Qin L, Hayashi M, et al. Therapeutic Potential of Centella asiatica and Its Triterpenes: A Review. Front Pharmacol. 2020;11:1–24.

Gohil KJ, Patel JA, Gaijar AK. Pharmacological review on Centella asiatica: A potential herbal cure-all. Indian J Pharm Sci. 2010;72(5):546–56.

Wollina U, Abdel-Naser MB, Mani R. A review of the microcirculation in skin in patients with chronic venous insufficiency: the problem and the evidence available for therapeutic options. Int J Low Extrem Wounds. 2006;5(3):169-80.

Tang B, Zhu B, Liang Y, Bi L, Hu Z, Chen B, Zhang K, Zhu J. Asiaticoside suppresses collagen expression and TGF-β/Smad signaling through inducing Smad7 and inhibiting TGF-βRI and TGF-βRII in keloid fibroblasts. Arch Dermatol Res. 2011;303:563-72.

Song J, Xu H, Lu Q, Xu Z, Bian D, Xia Y, Wei Z, Gong Z, Dai Y. Medcassoside suppresses migration of fibroblasts from keloids: involvement of p38 kinase and PI3K signaling pathways. Burns. 2012;38:677-84.

Ago MBN, Adifa DP. Benefits of Gotu Kola Leaf in Responding to Prevent The Form of Keloid in The Wound. Indones J Glob Health Res. 2020;2(1):23-8.

Howell N, Krings A, Braham R. Guide to the littoral zone vascular flora of Carolina bay lakes (U.S.A.). Biodivers Data J. 2016.

Pazyar N, Feily A. Garlic in dermatology. Dermatol Rep. 2011;3:e4.

Feily A, Namazi MR, Pazyar N, Saboktakin M, Saboktakin M. Garlic Extract as a Novel Addition to Antikeloid Armamentarium: An Untested Hypothesis. J Altern Complement Med. 2009;15(11):1153-4.

Shedoeva A, Leavesley D, Upton Z, Fan C. Wound healing and the use of medicinal plants. Evid Based Complement Altern Med. 2019;2019:1–31.

Kamath M. Pharmacokinetics of Curcumin: Problems and Promises. World J Pharm Res. 2020;9(5):2043–9.

Mehta M, Branford OA, Rolfe KJ. The evidence for natural therapeutics as potential anti-scarring agents in burn-related scarring. Burn Trauma. 2016;4(1):1–12.

Heppt MV, Breuninger H, Reinholz M, Feller-Heppt G, Ruzicka T, Gauglitz GG. Current strategies in the treatment of scars and keloids. Facial Plast Surg. 2015;31(4):386–95.

Gold MH, Berman B, Clementoni MT, Gauglitz GG, Nahai F, Murcia C. Updated international clinical recommendations on scar management: Part 1 - Evaluating the evidence. Dermatol Surg. 2014;40(8):817–24.

Grigoryan KV, Kampp JT. Summary and evidence grading of over-the-counter scar treatments. Int J Dermatol. 2020;59(9):1136–43.

Jenwitheesuk K, Surakunprapha P, Jenwitheesuk K, Kuptarnond C, Prathanee S, Intanoo W. Role of silicone derivative plus onion extract gel in presternal hypertrophic scar protection: A prospective randomized, double-blinded, controlled trial. Int Wound J. 2012;9(4):397–402.

Lingzhi Z, Meirong L, Xiaobing F. Biological approaches for hypertrophic scars. Int Wound J. 2020;17(2):405–18.

Khansa I, Harrison B, Janis JE. Evidence-based scar management: How to improve results with technique and technology. Plast Reconstr Surg. 2016;138(3):165S-178S.

Putra IB, Soebono H, Hadisahputra S, Bachtiar A. The Effect of Roselle (Hibiscus sabdariffa L.) Flowers Extract on the Apoptosis of Fibroblast Proliferation in Keloids. Maced J Med Sci. 2020;8(A):611-614.

He X, Bai Y, Zhao Z, Wang X, et al. Local and traditional uses, phytochemistry, and pharmacology of Sophora japonica L.: A review. J Ethnopharmacol. 2016.

Chen XH, Sun RS, Hu JM, et al. Attenuation of bleomycin-induced lung fibrosis by oxymatrine is associated with regulation of fibroblast proliferation and collagen production in primary culture. Basic Clin Pharmacol Toxicol. 2008;103:278–86.

Fan DL, Zhao WJ, Wang YX, Han SY, Guo S. Oxymatrine inhibits collagen synthesis in keloid fibroblasts via inhibition of transforming growth factor-β1/Smad signaling pathway. Int J Dermatol. 2012;51:463-72.

Qun WJ, Jiu NX. Effect of oxymatrine on cell proliferation, apoptosis, cell cycle and erk1 expression of the fibroblasts derived from hypertrophic scar and keloids. Chin J Minim Invasive Surg. 2011;11(2):259–63.

Shao ZM, Shen ZZ, Fontana JA, Barsky SH. Genistein’s “ER-dependent and independent” actions are mediated through ER pathways in ER-positive breast carcinoma cell lines. Anticancer Res. 2000;20:2409–16.

Theodorescu D, Laderoute KR, Calaoagan JM, Gulding KM. Inhibition of human bladder cancer cell motility by genistein is dependent on epidermal growth factor receptor but not p21ras gene expression. Int J Cancer. 1998;78:775–82.

Davis JN, Kucuk O, Sarkar FH. Genistein inhibits NF-kappa B activation in prostate cancer cells. Nutr Cancer. 1999;35:167–74.

Cao C, Li SR, Dai X, et al. Genistein inhibits proliferation and functions of hypertrophic scar fibroblasts. Burns. 2009;35(1):89–97.

Ye Q, Wang SJ, Chen JY, Rahman K, Xin HL, Zhang H. Medicinal plants for the treatment of hypertrophic scars. Hindawi Evid Based Complement Altern Med. 2015;1–15.
Share:

Z

Mendrofa, I., & Putra, I. B. (2025). The Role of Herbal Medicine for Hypertrophic Scars Management. Journal of Society Medicine, 4(1), 28–33. https://doi.org/10.71197/jsocmed.v4i1.191