Comparative Analysis of Ankle-Brachial Index in Chronic Myeloid Leukemia Patients Treated with Imatinib versus Nilotinib at Adam Malik Hospital
Authors
Abstract
Introduction: Chronic myeloid leukemia (CML) is commonly managed with tyrosine kinase inhibitors (TKIs) such as imatinib and nilotinib. However, these therapies are associated with cardiovascular risks, including peripheral arterial disease (PAD). This study compares the Ankle-Brachial Index (ABI), a non-invasive measure of PAD, in CML patients receiving imatinib or nilotinib at Adam Malik Hospital, Medan.
Methods: A cross-sectional study was conducted from December 2023 to February 2024 at Adam Malik Hospital. Forty-eight CML patients (34 on imatinib, 14 on nilotinib) were enrolled using consecutive sampling. ABI was measured to assess PAD prevalence, with values <0.9 indicating abnormality. Data were analyzed using independent t-tests and chi-square tests, with significance set at p<0.05.
Results: The mean age was 42.9 years (imatinib) and 49.1 years (nilotinib). Abnormal ABI values were observed in 20.6% (7/34) of imatinib-treated patients and 50% (7/14) of nilotinib-treated patients. The mean ABI for the left leg was significantly lower in the nilotinib group (0.91 ± 0.12) compared to the imatinib group (1.06 ± 0.11, p=0.017). A significant difference in ABI values between groups was confirmed (p=0.042, odds ratio 3.857), indicating a higher PAD risk with nilotinib.
Conclusion: Nilotinib therapy is associated with a higher incidence of PAD compared to imatinib in CML patients. These findings underscore the need for routine cardiovascular monitoring in TKI-treated patients and further research into the vascular effects of TKIs.
Similar Articles
- Aziz Achmad, Zainal Safri, Teuku Bob Haykal, Abdullah Afif Siregar, Nizam Zikri Akbar, Tengku Winda Ardini, Cut Aryfa Andra, Anggia Chairuddin Lubis, Relationship Between Neutrophil-Lymphocyte Ratio Value And Severity of Mitral Stenosis Due to Rheumatic Heart Disease in Outpatients at H. Adam Malik General Hospital Medan , Journal of Society Medicine: Vol. 3 No. 12 (2024): December
- Edlin, Mual Kristian Sinaga, Prolotherapy in Chronic Coccydynia , Journal of Society Medicine: Vol. 2 No. 2 (2023): February
- Muhammad Bayhaqi Dalimunthe, Andika Pradana, Amira Permatasari Tarigan, Rina Amelia, The Relationship between Malnutrition and Quality of Life in Stable Chronic Obstructive Pulmonary Disease Patients at Prof. Dr. Chairuddin P. Lubis Hospital Field , Journal of Society Medicine: Vol. 3 No. 9 (2024): September
- Defriyan Ramzi, Refli Hasan, Zainal Safri, Relationship between Atherogenic Index of Plasma (AIP) and Mayor Cardiovascular Event (MACE) in Patients with Acute Myocardial Infarction (IMA) with Percutaneous Coronary Intervention (PCI) in Haji Adam Malik Hospital , Journal of Society Medicine: Vol. 3 No. 5 (2024): May
- Cut Putri Hazlianda, Ade Gustina Siahaan, Autoimmune Blistering Disease in Children , Journal of Society Medicine: Vol. 2 No. 11 (2023): November
- Sharanjit Dhillon, Aida Fithrie, Chairil Amin Batubara, The Association between Waist Hip Ratio and Severity of Diabetic Peripheral Neuropaty in Diabetes Melitus Type 2 by Using Toronto Clinical Scoring System , Journal of Society Medicine: Vol. 2 No. 4 (2023): April
- Defriyan Ramzi, Harris Hasan, Abdul Halim Raynaldo, The Relationship Between Platelet and Lymphocyte Ratios and Left Atrial Thrombus Formation in Patients with Severe Mitral Stenosis due to Rheumatic Heart Disease at Haji Adam Malik Hospital Medan , Journal of Society Medicine: Vol. 4 No. 3 (2025): March
- Nahrisyah Nahrisyah, Kristo A. Nababan, Reduction of 75% in the Psoriasis Area and Severity Index (PASI) for Moderate-to-Severe Psoriasis Vulgaris , Journal of Society Medicine: Vol. 4 No. 2 (2025): February
- Olivia Monica Deneuve, Andika Pradana, Amira P Tarigan, The Relationship Between ICS LABA Administration and Blood Eosinophil Levels in COPD Patient at USU General Hospital , Journal of Society Medicine: Vol. 3 No. 12 (2024): December
- Billi, Muhammad Akbar, David Gunawan Umbas, Firdaus Hamid, Andi Kurnia Bintang, Mimi Lotisna, Estimated Glomerular Filtration Rate (eGFR) as a Predictor of 1-Month Clinical Outcome in First-Ever Acute Ischemic Stroke Patients , Journal of Society Medicine: Vol. 2 No. 12 (2023): December
<< < 1 2 3 4 5 6 7 8 9 10 > >>
You may also start an advanced similarity search for this article.