The Relationship Between Serum Apolipoprotein B Levels and Severity of Coronary Lesions Using The Syntax Score in Non-St Segment Elevation Acute Myocardial Infarction Patients at Haji Adam Malik General Hospital Medan

Enggar Sari Kesumawardani; Zainal Safri; Harris Hasan; Refli Hasan; Cut Aryfa Andra; Tengku Winda Ardini

doi:10.47353/jsocmed.v2i4.32

The Relationship Between Serum Apolipoprotein B Levels and Severity of Coronary Lesions Using The Syntax Score in Non-St Segment Elevation Acute Myocardial Infarction Patients at Haji Adam Malik General Hospital Medan

Enggar Sari Kesumawardani
Cardiology and Vascular Resident, Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia / Haji Adam Malik General Hospital, Medan, Indonesia
Zainal Safri
Cardiologist, Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia / Haji Adam Malik General Hospital, Medan, Indonesia
Harris Hasan
Cardiologist, Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia / Haji Adam Malik General Hospital, Medan, Indonesia
Refli Hasan
Cardiologist, Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia / Haji Adam Malik General Hospital, Medan, Indonesia
Cut Aryfa Andra
Cardiologist, Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia / Haji Adam Malik General Hospital, Medan, Indonesia
Tengku Winda Ardini
Cardiologist, Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia / Haji Adam Malik General Hospital, Medan, Indonesia

Abstract

Introduction: Acute coronary syndrome mainly occurs as a result of plaque rupture of atherosclerosis. Apolipoprotein B (apoB) is a large glycoprotein, playing a role in lipoprotein metabolism and human lipid transport reflecting the number of circulating atherogenic particles. The purpose of this study was to assess the relationship of serum apoB levels with coronary lesion severity.

Method: This is a cross-sectional study involving patients who was diagnosed with Non-ST Elevation Myocardial Infarction (NSTEMI) who underwent coronary angiography in November 2021 to July 2022. The NSTEMI criteria follow the Universal Definition of Myocardial Infarction and coronary severity is assessed using a SYNTAX score. Bivariate analysis was conducted looking for the relationship between apoB with SYNTAX scores with p<0.05 considered statistically significant.

Results: The subjects of the study is 70 people, dominated by male 50 patients (71.4%). The median age of the subjects was 56 (38-77) years. Median levels of apoB was 107 (32-150) mg/dL. The average SYNTAX score was 25.66 ± 10.83. Using the Pearson correlation test, it was shown that there is a significant correlation between apoB and coronary lesion severity obtained r=0.442 (p<0.001).

Conclusion: There is a significant correlation between apoB and coronary lesion severity using SYNTAX scores in NSTEMI patients.

Similar Articles

Suci Asriri Pradina Muslim, Hilfan Ade Putra Lubis , Ali Nafiah Nasution , The Relationship Between Low-Density Lipoprotein Cholesterol and Coronary Artery Calcium Score in Patients with Chronic Coronary Syndrome Without Diabetes Mellitus at RSUP Haji Adam Malik Medan , Journal of Society Medicine: Vol. 4 No. 3 (2025): March
Dian Primadia Putri, Rahmad Isnanta Sembiring, Tambar Kembaren, Putri Eyanoer, Relationship of D-dimer Value to Mortality in Covid-19 Patients with Acute Coronary Syndrome at Haji Adam Malik Hospital Medan , Journal of Society Medicine: Vol. 2 No. 4 (2023): April
Muhammad Hafiz Mahruzza Putra, Refli Hasan, Andika Sitepu, Harris Hasan, Andre Pasha Ketaren, Cut Aryfa Andra, Abdul Halim Raynaldo, Kamal Kharrazi Ilyas, Relationship between Coronary Artery Calcium Score (CACS) and Diastolic Dysfunction in Patients with Stable Coronary Heart Disease at Adam Malik General Hospital Medan , Journal of Society Medicine: Vol. 4 No. 6 (2025): June
Faisal Adam, Harris Hasan, T. Bob Haykal, Relationship Between Neutrophil-to-Lymphocyte Ratio and High-Density Lipoprotein with Major Cardiovascular Events in Acute Myocardial Infarction with ST-Segment Elevation Undergoing Primary Percutaneous Coronary Intervention at Adam Malik Hospital, Medan , Journal of Society Medicine: Vol. 4 No. 8 (2025): August
Nurvira Annisa Saragih, Alfansuri Kadri, Chairil Amin Batubara, Short-Term Prognostic Model for Non-Traumatic Intracerebral Hemorrhage Patients: A Combination of Four Score, FUNC Score, and ICH Score , Journal of Society Medicine: Vol. 3 No. 1 (2024): January
Ratna Mariana Tamba, Hilfan Ade Putra Lubis, Zulfikri Mukhtar, Andika Sitepu, Faisal Habib, Cut Aryfa Andra, T. Bob Haykal, The Relationship between Transient Ischemic Dilation (TID) and Severity of Coronary Artery Disease (CAD) in Patients with Chronic Coronary Syndrome (CCS) in Haji Adam Malik Medan, Indonesia , Journal of Society Medicine: Vol. 2 No. 9 (2023): September
Siti Alimahtun Sodiah Chaniago, Iskandar Nasution, Irina Kemala Nasution, The Association of Nutrition Status Towards The Outcome of Acute Ischemic Stroke Patients with Type-2 Diabetes Mellitus , Journal of Society Medicine: Vol. 2 No. 1 (2023): January
Yasdika Imam Taufik, Refli Hasan, Nizam Zikri Akbar, Triglyceride/High-Density Lipoprotein Ratio as a Predictor of Major Cardiovascular Events Within 6 Months Post-Treatment in Patients with Acute Myocardial Infarction and Type 2 Diabetes Mellitus at Haji Adam Malik General Hospital, Medan , Journal of Society Medicine: Vol. 4 No. 8 (2025): August
Siti Hasnita Oktavia Purba, Iskandar Nasution, R.A. Dwi Pujiastuti, The Correlation between Dehydration and Early Neurological Deterioration in Acute Hemorrhagic Stroke , Journal of Society Medicine: Vol. 3 No. 1 (2024): January
Defriyan Ramzi, Refli Hasan, Zainal Safri, Relationship between Atherogenic Index of Plasma (AIP) and Mayor Cardiovascular Event (MACE) in Patients with Acute Myocardial Infarction (IMA) with Percutaneous Coronary Intervention (PCI) in Haji Adam Malik Hospital , Journal of Society Medicine: Vol. 3 No. 5 (2024): May

<< < 1 2 3 4 5 6 7 8 9 10 > >>

You may also start an advanced similarity search for this article.

PDF

Published at

30. April 2023
https://doi.org/10.47353/jsocmed.v2i4.32
Issue:

Vol. 2 No. 4 (2023): April
Section:

Articles
Keywords:

Apolipoprotein B NSTEMI SYNTAX score Acute Coronary Syndrome
References:

WHO. Cardiovascular Disease (CVDs) fact sheets. World Health Organization. 2021. Available from: https://www.who.int/en/news-room/fact-sheets/detail/cardiovascular-diseases-(cvds) (Accessed: April, 10th 2022)

Vaduganathan M, Mensah G, Turco J. The Global Burden of Cardiovascular Diseases and Risk. J Am Coll Cardiol. 2022; 80 (25): 2361–2371. DOI: https://doi.org/10.1016/j.jacc.2022.11.005

Badan Penelitian dan Pengembangan Kesehatan RI. Riset Kesehatan Dasar (RISKESDAS) 2018. Laporan Nasional. 2018: 146-153.

Knuuti J, Wijns W, Saraste A, Capodanno D, Barbato E, Funck-Brentano C, et al. ESC Scientific Document Group, 2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes: The Task Force for the diagnosis and management of chronic coronary syndromes of the European Society of Cardiology (ESC). European Heart Journal. 2020; 41 (3): 407–477. DOI: https://doi.org/10.1093/eurheartj/ehz425

Kim MC, Kini AS, Fuster V. Definitions and Pathogenesis of Acute Coronary Syndromes. In : Walsh RA, Fang JC, & Fuster V, editor. Hurst’s the Heart Manual of Cariology 13th ed. New York: Mc Graw Hill. 2013; 249

Rhee, JW, Sabatine, MS., Lilly, L. S. Acute coronary syndrome. In: Lilly LS (ed.) Pathophysiology of Heart Disease: A Collaborative Project of Medical Students and Faculty, 5th edition. Baltimore: Lippincott of Williams and Wilkin. 2015; 166-176

Lin T, Wang L, Guo J, Liu P, Chen L, Wei M, et al. Association between serum LDL-C and APOB and syntax score in patients with stable coronary artery disease. Angiology. 2018; 69 (8): 724-9.

Suryaatmaja MFaktor resiko kardiovaskular/Aterosklerosis Apo A, Apo B, dan Lp (A). Dalam : Pendidikan Berkesinambungan Patologi Klinik. Jakarta: InternaPublishing. 2017.

Visseren FLJ, Mach F, Smulders YM, Carballo D, Koskinas KC, Bäck M, et al. ESC Guidelines on cardiovascular disease prevention in clinical practice: Developed by the Task Force for cardiovascular disease prevention in clinical practice with representatives of the European Society of Cardiology and 12 medical societies With the special contribution of the European Association of Preventive Cardiology (EAPC), European Heart Journal. 2021; 42 (34): 3227–3337. DOI: https://doi.org/ 10.1093/eurheartj/ehab484

Kraml P, Syrovatka P, Stipek S. Hyperlipoproteinemia impairs endothelium-dependent vasodilation. Physiol Res. 2004; 53 (5): 471-480.

Chiha J, Mitchell P, Gopinath B, Burlutsky G, Plant A, Kovoor P, et al. Prediction of Coronary Artery Disease Extent and Severity Using Pulse Wave Velocity. PLoS ONE. 2016; 11(12): e0168598. DOI: https://doi.org/10.1371/journal.pone.0168598

Serruys PW, Morice MC, Kappetein AP. Percutaneous coronary intervention versus coronary-artery bypass grafting for severe coronary artery disease. N Engl J Med. 2009; 360: 961–72.

Boyraz B, Peker T. Comparison of SYNTAX and Gensini Scores in the Decision of Surgery or Percutaneous Revascularization in Patients With Multivessel Coronary Artery Disease. Cureus. 2022; 14 (2): e22482. DOI: https://doi.org/10.7759/cureus.22482

Farooq V, Head SJ, Kappetein AP, Serruys PW. Widening clinical applications of the SYNTAX Score. Heart. 2013; 100(4): 276–287. DOI: https://doi.org/10.1136/heartjnl-2013-304273

Nurulita A, Bahrun U, Arif M. Perbandingan kadar Apolipoprotein B dan fraksi lipid sebagai Faktor Resiko Sindrom Koroner Akut. JST Kesehatan; 2011. 1 (1): 94-100

Hua R, Li Y, Li W, Wei Z, Yuan Z, Zhou J. Apolipoprotein B/A1 Ratio Is Associated with Severity of Coronary Artery Stenosis in CAD Patients but Not in Non-CAD Patients Undergoing Percutaneous Coronary Intervention. Dis Markers. 2021; 20 (21): 1-10

Khadem-Ansari MH, Rasmi Y, Rahimi-Pour A, Jafarzadeh M. The association between serum apolipoprotein A-I and apolipoprotein B and the severity of angiographical coronary artery disease. Singapore Med J. 2009; 50 (6): 610-3. PMID: 19551315.

Mashayekhi NR, Sadrnia Saeid, Chehrei A, Javaheri E. The Correlationn between serum ApoA1 and B and Coronary Artery Disease as well as its Severity. Int Cardiovasc Res J. 2014: 8 (1):1-5

Ohwada T, Sakamoto T, Kanno Y, Yokokawa S, Amami K, Nakazato K, et al. Apolipoprotein B correlates with intra-plaque necrotic core volume in stable coronary artery disease. PLoS One. 2019; 14 (2): e0212539. DOI: https://doi.org/10.1371/journal.pone.0212539. PMID: 30779793

Siallagan Delpiana, Siregar Jelita, Hasan Refli. Korelasi kadar apolipoprotein B dengan luas lesi koroner berdasarkan skor gensini pada pasien penyakit jantung koroner. Tesis Magister Kedokteran Klinik Fakultas Kedokteran Universitas Sumatera Utara. 2022

PERKI. Pedoman Tatalaksana Sindrom Koroner Akut. Edisi Keempat. Perhimpunan Dokter Spesialis Kardiovaskular Indonesia. 2021

Pagana KD, Pagana TJ. Manual of Diagnostic and Laboratory Test. 2006. Third Edition. Elsevier.USA

Yaseen IR, El-Leboudy MH, El-Deeb HM. The relation between ApoB/ApoA-1 ratio and the severity of coronary artery disease in patients with acute coronary syndrome. The Egyptian Heart Journal. 202: 1
Share:

Z

Kesumawardani, E. S., Safri, Z., Hasan, H., Hasan, R., Andra, C. A., & Ardini, T. W. (2023). The Relationship Between Serum Apolipoprotein B Levels and Severity of Coronary Lesions Using The Syntax Score in Non-St Segment Elevation Acute Myocardial Infarction Patients at Haji Adam Malik General Hospital Medan . Journal of Society Medicine, 2(4), 137–147. https://doi.org/10.47353/jsocmed.v2i4.32