Catechol-O-Methyltransferase (COMT) Enzyme Level In Preoperative Anxiety Patients

Akhyar Hamonangan Nasution; Aznan Lelo

doi:10.47353/jsocmed.v1i1.5

Catechol-O-Methyltransferase (COMT) Enzyme Level In Preoperative Anxiety Patients

Akhyar Hamonangan Nasution
Department of Anesthesiology and Intensive Care, Faculty of Medicine, Universitas Sumatera Utara, Indonesia
Aznan Lelo
Department of Pharmacology and Therapeutics, Universitas Sumatera Utara, Medan, Indonesia

Abstract

Background: Incidence of perioperative anxiety is very high, many preoperative patient experience anxiety . Thiamine acts as an essential nutrition funtionate as cofactor enzyme in most of mitochondria in brain. Brain is very susceptible to thiamine deficiency because its dependency on mitochondrial ATP production. Decreased ATP production result in inhibition of COMT activity. Low COMT levels indicated tendency for anxiety. The aim of this study is to determine the effect of thiamine in increasing COMT enzyme levels in patient with preoperative anxiety

Methods : A true experiment with pretest-posttest control group and double-blind design conducted at the Department of Anesthesia and Intensive Care of University of North Sumatra in August 2019. The 60 patients were analyzed which were planned for and done an elective surgery under general anesthesia. Preoperative anxiety was measured with Amsterdam Preoperative Anxiety and Information Scale (APAIS) and COMT enzyme level measured by ELISA assays.

Results : The results showed that from 64 patients had incidence of preoperative anxiety in this study was 48.3%. We found that there is significant differences in COMT enzyme levels in thiamine group compared to control (p value = 0.001). In addition, it was seen that in thiamine group had an increased COMT levels from 0.96 ng/dL to 1.78 ng/dL, while in control group there also slight increasing from 0.44 ng/dL to 0.78 ng/dL. This show that increase in COMT levels is greater in thiamine group than control group.

Conclusion : Thiamine can cause increasing COMT enzyme levels in patients scheduled for elective surgery with preoperative anxiety under general anesthesia

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Published at

8. October 2022
https://doi.org/10.47353/jsocmed.v1i1.5
Issue:

Vol. 1 No. 1 (2022): October
Section:

Articles
Keywords:

Preoperative Anxiety Thiamine General Anesthesia
References:

Mitchell M. Anesthesia type, gender and anxiety. J Perioper Practice. 2013;23(3):41–7.

Pohjavaara P, Telaranta T, Väisänen E. The role of the sympathetic nervous system in anxiety: Is it possible to relieve anxiety with endoscopic sympathetic block?. Nord J Psychiatry. 2003;57(1):55–60.

Celik F, Edipoglu IS. Evaluation of preoperative anxiety and fear of anesthesia using APAIS score. Eur J Med Res. 2018;23(1):41.

Mathew RJ, Ho BT, Kralik P, Taylor D, Semchuk K, Weinman M, et al. Catechol-O-methyltransferase and catecholamines in anxiety and relaxation. Psychiatry Res. 1;3(1):85–91.

Dhir S, Tarasenko M, Napoli E, Giulivi C. Neurological, Psychiatric, and Biochemical Aspects of Thiamine Deficiency in Children and Adults. Front Psychiatry. 2019 4;10:207.

Osiezagha K, Ali S, Freeman C, Barker NC, Jabeen S, Maitra S, et al. Thiamine deficiency and delirium. Innov Clin Neurosci. 2013;10(4):26–32.

Biddiss E, Knibbe TJ, McPherson A. The effectiveness of interventions at reducing anxiety in health care waiting spaces: a systematic review of randomized and nonrandomized trials. Anesth Analg. 2014;119(2):433–48.

Pittman S, Kridli S. Music intervention and preoperative anxiety: an integrative review. Int Nurs Rev. 2011;58(2):157–63.

Desbonnet L, Tighe O, Karayiorgou M, Gogos JA, Waddington JL, O'Tuathaigh CMP. Physiological and behavioral responsiveness to stress and anxiogenic stimuli in COMT-deficient mice. Behav Brain Res. 2012 17;228(2):351–8.

Tunbridge EM. The Catecol-O-Methyltransferase Gene. In: International review of neurobiology. 2010. p. 7–27.

Ursini G, Bollati V, Fazio L, Porcelli A, Iacovelli L, Catalani A, et al. Stress-Related Methylation of the Catecol-O-Methyltransferase Val158 Allele Predicts Human Prefrontal Cognition and Activity. J Neurosci. 2011 May 4:31(18):6692–8.

Vinh Quốc Lương K, Thi L, Nguyễn H. The Impact of Thiamine Treatment on Generalized Anxiety Disorder. Int J Clin Med. 2011;2:439–43.

Pearson S, Maddern GJ, Fitridge R. The role of pre-operative state-anxiety in the determination of intra-operative neuroendocrine responses and recovery. Br J Health Psychol. 2005;10(2):299–310.

Walder DJ, Trotman HD, Cubells JF, Brasfield J, Tang YL, Walker EF. Catecol-O-methyltransferase modulation of cortisol secretion in psychiatrically at-risk and healthy adolescents. Psychiatrists Genet. 2010 Aug;20(4):166–70.

Vadhanan P, Tripaty DK, Balakrishnan K. Pre-operative anxiety amongst patients in a tertiary care hospital in India- a prevalence study. J Soc Anesthesiol Nepal. 2017;4(1):5–10.

Fortacín CB, Puig CE, Fortuño ML. Effectiveness of preoperative visit on anxiety, pain and wellbeing. Enferm Glob. 2015;14(3):29–51.

Ruenwongsa P, Pattanavibag S. Impairment of acetylcholine synthesis in thiamine deficient rats developed by prolonged tea consumption. Life Science [Internet]. 1984 Jan 23 [cited 2019 Sep 27];34(4):365–70.

Wilke RA, Hillard CJ. Decreased Adrenal Medullary Catecholamine Release in Spontaneously Diabetic BB-Wistar Rats: Role of Hypoglycemia. Diabetes [Internet]. 1994 May 1 [cited 2019 Sep 28];43(5):724–9.

McGregor NR. Catecol O-Methyltransferase: a review of the gene and enzyme. J Dent Clin Research. 2014;1(1):7–26.
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Hamonangan Nasution, A., & Lelo, A. (2022). Catechol-O-Methyltransferase (COMT) Enzyme Level In Preoperative Anxiety Patients . Journal of Society Medicine, 1(1), 25–30. https://doi.org/10.47353/jsocmed.v1i1.5