Association between Coagulation Profile and Platelet Lymphocyte Ratio with Karnofsky Performance Status Scale In Brain Tumor Patients
Authors
Abstract
Introduction: Patients with tumor usually show abnormal laboratory coagulation tests, indicating a subclinical hypercoagulable state that contributes to morbidity and mortality. Hematologic markers such as the platelet-lymphocyte ratio (PLR) can be used as an index of tumor progression, high PLR is associated with morbidity and mortality in patients with primary or metastatic tumors. KPS is a method that is widely used to assess the functional status of a patient. The aim of this study is to determine the relationship between coagulation profile and platelet-lymphocyte with Karnofsky Performance Status Scale in Brain Tumor Patients.
Method: This study was an observational analytic study with a cross-sectional design using primary data sources taken consecutively from all brain tumor patients who were hospitalized in Inpatient Room at Haji Adam Malik General Hospital Medan who met the inclusion criteria. The parameters analyzed were Prothrombin Time (PT), Activated Partial Thromboplastin Time (aPTT), D dimer (DD), and PLR. Clinical outcome of brain tumor patients was assessed using KPS. To assess the relationship between coagulation marker factors and the ratio of platelets to lymphocytes to KPS, the Spearman and Gamma tests were used.
Results: Of the 30 research subjects analyzed, the number of female subjects was comparable to that of males (50%). The highest age is in the age range of 61-70 years by 30%. The highest level of education was high school at 40%, the most research subjects were housewives at 33.3% and the most types of brain tumors were primary brain tumors at 56.7%. The highest KPS score during treatment was found in the <70 group of 76.7%. From the correlation test, it was found that there was a strong, significant relationship between the values of PT (p<0.02 r = -0.731), APTT (p<0.013 r = -0.761), D-dimer (p<0.001 r = -0.737) and PLR (p<0.001 r = 0.78) on the clinical outcome of brain tumor patients assessed by KPS.
Conclusion: There is a strong relationship between PT, APTT, D-dimer and PLR values on KPS in patients with brain tumor.
Similar Articles
- Utama Hadiputra Surbakti, R.A. Dwi Pujiastuti, Kiking Ritarwan, Associations between Depression and Anxiety with Sleep Quality in Post Stroke Patients , Journal of Society Medicine: Vol. 2 No. 3 (2023): March
- Rendi Sidiq, Bastian Lubis, Yutu Solihat, Comparison of Pre-Loading Fluid With Norepinephrine Toward Mean Arterial Pressure (MAP) In Sepsis Patients In Intensive Care Unit (ICU) of Haji Adam Malik General Hospital, Medan , Journal of Society Medicine: Vol. 1 No. 2 (2022): November
- Intan Fachrina, Syamsul Bihar, Fajrinur Syarani, Correlation of Bronchoscopy Visualization With Cell Type in Lung Cancer Patients at Haji Adam Malik Hospital Medan 2023 , Journal of Society Medicine: Vol. 3 No. 10 (2024): Oktober
- Dina Khairunnisah, Harris Hasan, Abdul Halim Reynaldo, Teuku Bob Haykal, Yuke Sarastri, The Relationship Between Aerobic Physical Exercise to Functional Capacity in Heart Failure Patients at Haji Adam Malik General Hospital Medan , Journal of Society Medicine: Vol. 2 No. 9 (2023): September
- Diko Hamonangan Saragih, Cut Aria Arina, Iskandar Nasution, The Association Between ASPECTS Score and Dysphagia in Acute Ischemic Stroke Patients , Journal of Society Medicine: Vol. 2 No. 7 (2023): July
- Siti Hasnita Oktavia Purba, Iskandar Nasution, R.A. Dwi Pujiastuti, The Correlation between Dehydration and Early Neurological Deterioration in Acute Hemorrhagic Stroke , Journal of Society Medicine: Vol. 3 No. 1 (2024): January
- Mukhamad Faried, Franciscus Ginting, Tambar Kembaren, Putri Chairani Eyanoer, Factor Influencing Mortality in Moderate - Severe Covid-19 Patients In Tertiary Hospital, Indonesia , Journal of Society Medicine: Vol. 2 No. 7 (2023): July
- Batian Lubis, Dis Bima P Purwaamidjaja, Mayang Indah Lestari, Faisal, Muhammad Husni Thamrin, Febri Akhmad Belinda, A Case Series of Bleeding Complication Post Percutaneous Dilatational Tracheostomy and Management , Journal of Society Medicine: Vol. 2 No. 12 (2023): December
- Clarisa Monica, Taufik Sungkar, Ilhamd, Correlation between Helicobacter Pylori Caga Antibody Serum and Gastric Premalignant Lesions in Helicobacter Pylori Patients , Journal of Society Medicine: Vol. 2 No. 10 (2023): October
- Adi Retno, Evo Elidar Harahap, Bayu Rusfandi Nasution, Relationship between Stage of Chronic Kidney Disease with Cardiomegaly Imaging in Posteroanterior Chest X-Ray at Haji Adam Malik Hospital Medan , Journal of Society Medicine: Vol. 2 No. 8 (2023): August
You may also start an advanced similarity search for this article.