Relationship between Homeostatic Model Assessment for Insulin Resistance and Waist Hip Ratio with Cognitive Function in Type 2 Diabetes Mellitus

Fasihah Irfani Fitri; Oriza Novita; Haflin Soraya Hutagalung

doi:10.47353/jsocmed.v2i7.60

Relationship between Homeostatic Model Assessment for Insulin Resistance and Waist Hip Ratio with Cognitive Function in Type 2 Diabetes Mellitus

Fasihah Irfani Fitri
Lecturer in the Department of Neurology, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia
Oriza Novita
Resident in Department of Neurology, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia
Haflin Soraya Hutagalung
Lecturer in the Department of Neurology, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia

Abstract

Introduction: Cognitive impairment is a common complication of Type 2 Diabetes Mellitus (T2DM) in which the underlying mechanism are insulin resistance and associated central obesity. Homeostatic model assessment of insulin resistance (HOMA-IR) and waist-hip ratio (WHR) have been used as markers for insulin resistance and central obesity, respectively, but their direct association with cognition remains unclear. This study was conducted to determine the relationship between HOMA-IR and WHR with cognitive function in T2DM patients.

Method: This was a correlative analytic study with a cross sectional design involving T2DM pateints. The HOMA-IR was assessed based on blood laboratory results, the WHR was measured by dividing circumference of the waist by the circumference of the hips and cognitive function was assessed using the Montreal Cognitive Assessment Indonesian Version (MoCA-INA).

Results: : There were 56 patients included in the study. There was no significant relationship between HOMA-IR and cognitive function in T2DM patients (p=0.276; r=0.148). There was also no significant relationship between WHR and cognitive function (p = 0.499; r = 0.092).

Conclusion: The HOMA-IR and WHR were not correlated with cognitive function in T2DM.

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Published at

31. July 2023
https://doi.org/10.47353/jsocmed.v2i7.60
Issue:

Vol. 2 No. 7 (2023): July
Section:

Articles
Keywords:

cognitive MOCA-INA HOMA-IR waist to hip ratio diabetes mellitus
References:

Lin X, Xu Y, Pan X, Xu J, Ding Y, Sun X, et al. Global, regional, and national burden and trend of diabetes in 195 countries and territories: an analysis from 1990 to 2025. Scientific Reports. 2020;10:1-11.

Sun L, Diao X, Gang X, Lv Y, Zhao X, Yang S, et al. Risk Factors for Cognitive Impairment in Paitents with Type 2 Diabetes. Journal of Diabetes Research. 2020:1-10.

Damanik J, Yunir E. Type 2 Diabetes Mellitus and Cognitive Impairment. Acta Med Indones - Indones J Intern Med. 2021;53(2):213-20

Tsalissavrina I, Tritisari KP, Handayani D, Kusumastuty I, Arietiningsih AD, Armetristi F. Hubungan Lama Terdiagnosa Diabetes dan Kadar Glukosa Darah Dengan Fungsi Kognitif Penderita Diabetes Tipe 2 Di Jawa Timur. Jurnal AcTion. 2018;3(1):28–33.

Sastrawan MG, Sjahrir H, Iqbal KM. Hubungan Kadar Hemoglobin Terglikasi (HbA1c) dengan Working Memory pada Pasien Diabetes Melitus Tipe-2 dan Prediabetes. Repository USU. 2018.

Oktavia AI, Isnuwardana R, Rotinsulu DJ. Faktor-Faktor yang Mempengaruhi Fungsi Kognitif pada Pasien Diabetes Mellitus Tipe 2 di RSUD Abdul Wahab Sjahranie Samarinda. Universitas Mulawarman Samarinda. 2014.

Duron E, Olivier H. Vascular risk factor, cognitive decline and dementia. Vasc Health Risk Manag. 2008;4(2): 369-81

Paputungan SR, Sanusi H. Peranan Pemeriksaan Hemoglobin A1c pada Pengelolaan Diabetes Melitus. Cermin Dunia Kedokteran. 2014;41(9):650-55.

Wallace TM, Levy JC, Matthews DR (2004) Use and abuse of HOMA modeling. Diabetes Care 27: 1487–1495.

Lee CH, Shih AZL, Woo YC, Fong CHY, Leung OY, Janus E, et al. Optimal Cut-Offs of Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) to Identify Dysglycemia and Type 2 Diabetes Mellitus: A 15-Year Prospective Study in Chinese. PloS ONE. 2016;11(9):1-11

Lestari AAW. Resistensi Insulin: Definisi, Mekanisme dan Pemeriksaan Laboratoriumnya. 2011.

Yang XY, Shao MJ, Zhou Q, Xia Y and Zou HQ. Association of waist-to-hip ratio with insulin resistance in non-diabetic normal-weight individuals: a crosssectional study. Journal of Southern Medical University. 2017;37(11):p.1540-44

Zhang T, Yan R, Chen Q, Ying X, Zhai Y, Li F, Wang X, He F, Ye C, Lin J. Body mass index, waist-to-hip ratio and cognitive function among Chinese elderly: a cross-sectional study. BMJ Open. 2018 Oct 18;8(10):e022055.

Husein N, Silvia L, Yetty R dkk. Uji Validitas dan Reabilitas Montreal Cognitive Assessment Versi Indonesia (MoCA-Ina) Untuk Skrining Gangguan Fungsi Kognitif. Neurona Neuro Sains. 2010;27(4):15–22.

Nasreddine ZS, Phillips NA, Bedirian V, Charbonneau S, Whitehead V, Collin I, et al. The Montreal Cognitive Assessment, MoCA:a brief screening tool for mild cognitive impairment. J Am Geriatr Soc. 2005;53

Riset Kesehatan Dasar (RISKESDAS). Badan Penelitian dan Pengembangan Kesehatan Kementerian Kesehatan Republik Indonesia (Balitbangkes Kemenkes) 2013. Jakarta. 2018.

Tambunan LPS, Ritarwan K, Pujiastuti RA. Hubungan Antara Easy Sleep Apnea Predictor (ESAP) Dengan Risiko Obstructive Sleep Apnea Dan Gangguan Fungsi Kognitif Pada Pasien Diabetes Melitus Tipe2. Repository USU. 2021.

Trisnawati SK, Setyorogo S. Faktor Risiko Kejadian Diabetes Melitus Tipe II di Puskesmas Kecamatan Cengkareng Jakarta Barat Tahun 2012. Jurnal Ilmiah Kesehatan. 2013; 5(1):6–11.

Lalithambika CV, Arun CS, Saraswathy LA, Bhaskaran R. Cognitive Impairment and its Association with Glycemic Control in Type 2 Diabetes Mellitus Patients. Indian J Endocrinol Metab. 2019;23(3):353-6

Purwoningsih E, Purnama M. Perbandingan Faktor Perilaku Suku Batak dan Melayu Terhadap Kejadian Diabetes Melitus Tipe 2 di RSUD Dr. Tengku Mansyur Tanjung Balai. Ibnu Sina Biomedika. 2017;1(2):1-15

Tambunan LPS, Sjahrir H, Arina CA. The Difference of Stroke Risk Factor between Bataknese and Non Bataknese at H. Adam Malik General Hospital Medan. Indonesian Journal of Medicine. 2019;4(2):122-34.

Kong SH, Park YJ, Lee JY, Cho N, Moon MK. Insulin Resistance is Associated with Cognitive Decline Among Older Koreans with Normal Baseline Cognitive Function: A Prospective Community-Based Cohort Study. Scientific Reports. 2018:1-9

Zhao H, Wu C, Zhang X, Wang L, Sun J, Zhuge F. Insulin Resistance Is a Risk Factor for Mild Cognitive Impairment in Elderly Adults with T2DM. Open Life Sci. 2019;14:255-61.

Muthiah S, Kanagamuthu R, Mohanraj S, Lakshmi KN. Assessment of memory and cognitive functions in controlled and uncontrolled Type 2 diabetes mellitus patients. National Journal of Physiology, Pharmacy and Pharmacology. 2019;9(2):140-45

Preetam K, Chandrashekar NKT, Krishnappa R. Evaluation of Neurocognitive Disorder in Patients with Type 2 Diabetes Mellitus. International Journal of Nutrition, Pharmacology, Neurological Diseases. 2022:247-52

Murman D. The Impact of age on cognition. Pubmed Central Journal. 2015; 36(3):111-21.

Perhimpunan Dokter Spesialis Saraf Indonesia. Panduan Nasional Praktik Klinik Diagnosis dan Penatalaksanaan Demensia. Jakarta: Perdossi; 2015.

Geijselaers SLC, Sep SJS, Claessens D, Schram MT, van Boxtel MPJ, Henry RMA, et al. The role of hyperglycemia, insulin resistance, and blood pressure in diabetes-associated differences in cognitive performance-the maastricht study. Care.Diabetesjournal.org. 2017;40(11):1537-47.

Vlassara H, Palace MR. Diabetes and advanced glycation endproducts. J Intern Med. 2002;251(2):87-101.

Yaffe K, Kanaya A, Lindquist K, Simonsick EM, Harris T, Shorr RI, Tylavsky FA, et al. The metabolic syndrome, inflammation, and risk of cognitive decline. JAMA. 2004;292(18):2237-42.

Ma W, Zhang H, Wu N , Liu Y , Han P , Wang P, et al. Relationship between obesity-related anthropometric indicators and cognitive function in Chinese suburb-dwelling older adults. PLoS ONE. 2020;10(40):1-14

Singh-Manoux A, Dugravot A, Shipley M, Brunnerb EJ, Elbaza A, Sabiaa S, et al. Obesity trajectories and risk of dementia: 28 years of follow-up in the Whitehall II Study. Alzheimers Dement. 2018;14(2):178-86.

Yerrapragada DB, Rao CR, Karunakaran K, Lee HSE. Cognitive Dysfunction Among Adults With Type 2 Diabetes Mellitus in Karnataka, India. Ochsner Journal. 2019;19(3):227-34.

Zhen YF, Liu XY, Li YK, Fang H, Cassidy RM, Zhang XY. Association of Brain-Derived Neurotrophic Factor With Cognitive Function: An Investigation of Sex Differences in Patients With Type 2 Diabetes. Psychosomatic Medicine. 2019;81(6):488-94

Ntlholang O, McCarroll K, Laird E, Molloy AM, Ward M, McNulty H, et al. The relationship between adiposity and cognitive function in a large community-dwelling population: data from the Trinity Ulster Department of Agriculture (TUDA) ageing cohort study. British Journal of Nutrition. 2018;120:517-27.

Berbegal M, Tomé M, SanSegundo MS, Martí AZ, Sánchez JA. Memory Function Performance Individuals Classified as Overweight, Obese and Normal Weight. Frontiers. 2022.1-11

Septyaningrum N, Martini S. Lingkar Perut Mempunyai Hubungan Paling Kuat Dengan Kadar Gula Darah. Jurnal Berkala Epidemiologi. 2014;2(1):48-58

Debette S, Seshadri S, Beiser A, Au R, Himali JJ, Palumbo C, et al. Midlife vascular risk factor exposure accelerates structural brain aging and cognitive decline. Neurology. 2011;77:461-8.

Tinta I, Sumarni. Hubungan Obesitas Sentral Dengan Memori Jangka Pendek Mahasiswa Fakultas Kedokteran Universitas Tadulako. Healthy Tadulako Journal. 2019;5(3):1-5
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Fitri, F. I., Novita, O., & Hutagalung, H. S. (2023). Relationship between Homeostatic Model Assessment for Insulin Resistance and Waist Hip Ratio with Cognitive Function in Type 2 Diabetes Mellitus. Journal of Society Medicine, 2(7), 219–226. https://doi.org/10.47353/jsocmed.v2i7.60