Current Pathogenesis and Treatment of Cutaneous Lupus Erythematosus

Cut Putri Hazlianda; Ika Diamanda

doi:10.47353/jsocmed.v2i12.107

Current Pathogenesis and Treatment of Cutaneous Lupus Erythematosus

Cut Putri Hazlianda
Department of Dermatology Venereology and Aestethic, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia
Ika Diamanda
Department of Dermatology Venereology and Aestethic, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia

Abstract

Lupus erythematosus (LE) is a chronic autoimmune illness with a broad range of clinical symptoms. These conditions can range from systemic lupus erythematosus (SLE), which affects different organ systems in the body, to cutaneous lupus erythematosus (CLE), which affects only the skin. The precise pathophysiology of CLE is unknown, although it appears to include a complicated interaction of genetic predisposition and environmental stimuli such as UV light, medications, trauma, and hormones. The emergence of the inflammatory infiltrate seen in CLE lesions has also been documented in several studies; this information is crucial for figuring out which specific inflammatory mediators are responsible for tissue damage. Currently prescribed medications for CLE often include antimalarials, systemic corticosteroids, immunosuppressants, and immunomodulators; cytotoxic drugs are only used in the most severe instances.

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Published at

31. December 2023
https://doi.org/10.47353/jsocmed.v2i12.107
Issue:

Vol. 2 No. 12 (2023): December
Section:

Articles
Keywords:

Lupus erythematosus Cutaneous lupus erythematosus Pathogenesis Treatment
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Hazlianda, C. P., & Diamanda, I. (2023). Current Pathogenesis and Treatment of Cutaneous Lupus Erythematosus. Journal of Society Medicine, 2(12), 392–402. https://doi.org/10.47353/jsocmed.v2i12.107