Relationship between Angiotensin Converting Enzyme (ACE) and Cellulite

Annisa Astari; Imam Budi Putra; Nelva Karmila Jusuf

doi:10.47353/jsocmed.v3i3.133

Relationship between Angiotensin Converting Enzyme (ACE) and Cellulite

Annisa Astari
Resident of Dermatology and Venereology Department, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia
Imam Budi Putra
Department of Dermatology and Venereology, Faculty of Medicine, Universitas Sumatera Utara, Prof. Dr. Chairuddin P. Lubis USU Hospital, Medan, Indonesia
Nelva Karmila Jusuf
Department of Dermatology and Venereology, Faculty of Medicine, Universitas Sumatera Utara, Prof. Dr. Chairuddin P. Lubis USU Hospital, Medan, Indonesia

Abstract

Introduction: Cellulite is a local metabolic disorder in subcutaneous tissue characterized by changes in skin topography, occurring in parts of the body with a large accumulation of fat tissue, especially thighs, buttocks, hips, and abdomen. Angiotensin converting enzyme is a zinc metallopeptidase, distributed on the surface of endothelial cells. Increased ACE levels cause microcirculation disorders, adipocyte hypertrophy, increased extracellular matrix, and stimulate the emergence of inflammatory cytokines which will cause an increase in the inflammatory response in the tissue, stimulate fibrogenic response and influences the appearance of cellulite. The aim of this study was too determine the relationship between ACE and cellulite.

Method: This study was an observational study with a cross-sectional design of 40 cellulite patients and 40 controls. Each patient underwent history, dermatological examination, and blood sampling to assess ACE levels by ELISA test. These data were analyzed statistically using the Chi square test.

Results: The mean ACE level in cellulite was 66.78±15.38 µg/ml. The highest age with cellulite was 26–35 years 17 subjects (42.5%). Most of them had a family history of cellulite from their mother 22 subjects (55%). The majority of cellulite are located on the femoral and gluteus regions by 27 subjects (67.5%). The result of this study showed that there was a relationship between high ACE levels causing a risk of 4.5 times for cellulite (p = 0.002).

Conclusion: There is a relationship between ACE levels and cellulite.

Similar Articles

Fitriend Syahputri, Imam Budi Putra, Nelva K. Jusuf, Relationship between Plasma Fibronectin Levels and Stretch Marks , Journal of Society Medicine: Vol. 3 No. 4 (2024): April
Ilham Habib Djarkoni, Muhammad Iqbal Basri, Muhammad Akbar, Firdaus Hamid, Andi Kurnia Bintang, Jumraini Tamasse, High Density Lipoprotein (HDL) Level and Blood Urea Nitrogen (BUN)/Creatinin Ratio Relationship with One-Month Outcome in Acute Ischemic Stroke Patients , Journal of Society Medicine: Vol. 2 No. 12 (2023): December
Rizka Farahin Assania, Elvita Rahmi Daulay, Refli Hasan, Association of Risk Factors for Coronary Artery Disease with The Incidence of Abdominal Aortic Calcification On Abdominal CT-Scan Imaging in H. Adam Malik General Hospital , Journal of Society Medicine: Vol. 2 No. 3 (2023): March
Dia Tri Susanti, Gema Nazri Yanni, Johannes H. Saing, Erna Mutiara, Aridamuriany D. Lubis, Olga R. Siregar, Correlation of Fibrinogen Level with PELOD-2 Score As A Predictive Factor For Mortality in Pediatric Sepsis , Journal of Society Medicine: Vol. 2 No. 11 (2023): November
Indah Nasution, Karina Sugih Arto, Bugis Mardina Lubis, Correlation between Glycated Hemoglobin and Calcium Levels in Pediatric with Type 1 Diabetes Mellitus , Journal of Society Medicine: Vol. 2 No. 11 (2023): November
Astry Amelia Harahap, Alwi Thamrin Nasution, Rahmat Isnanta, The Relationship Between Serum Ferritin Levels and Left Ventricular Function in Patients Undergoing Hemodialysis , Journal of Society Medicine: Vol. 2 No. 10 (2023): October
Ade Irma, Elvita Rahmi Daulay, Anggia Chairuddin Lubis, Measurement of Thoracic Aortic Diameter Using Contrast-Enhanced CT Chest Based on Age, Gender, and Hypertension , Journal of Society Medicine: Vol. 2 No. 3 (2023): March
Novery Simbolon, Pandia Pandiaman, Pradana Andika , Factors Affecting Lung Function in Patients with Drug-Sensitive Tuberculosis after Treatment. , Journal of Society Medicine: Vol. 3 No. 10 (2024): Oktober
M. Isfan Rialdy, Nizam Zikri Akbar, T. Bob Haykal, Andre Pasha Ketaren, Cut Aryfa Andra, Yuke Sarastri, The Relationship between D-Dimer Levels and Coronary Lesion Severity in Patients with Acute Myocardial Infarction with ST-Segment Elevation at Haji Adam Malik Hospital Medan , Journal of Society Medicine: Vol. 2 No. 9 (2023): September
Olivia Monica Deneuve, Andika Pradana, Amira P Tarigan, The Relationship Between ICS LABA Administration and Blood Eosinophil Levels in COPD Patient at USU General Hospital , Journal of Society Medicine: Vol. 3 No. 12 (2024): December

<< < 1 2 3 4 5 6 7 8 > >>

You may also start an advanced similarity search for this article.

PDF

Published at

31. March 2024
https://doi.org/10.47353/jsocmed.v3i3.133
Issue:

Vol. 3 No. 3 (2024): March
Section:

Articles
Keywords:

Cellulite Angiotensin Converting Enzyme ACE levels Gynoid lipodystrophy Risk factors
References:

Arora G, Patil A, Hooshanginezhad Z, Fritz K, Salavastru C, Kassir M, et al. Cellulit: Presentation and Management. Journal of Cosmetic Dermatology. 2022; 00: 1–9.

Ortonne JP, Zartarian M, Verschoore M, Roussel CQ, Duteil L. Cellulite and skin ageing: is there any interaction?. Journal European Academy of Dermatology and Venereology. 2008; 827-834.

Bacci PA, Leibaschoff. Pathophysiology of Cellulite. In Social Impact of Cellulite and Its Impact on Quality of Life: Haxel D, Haxel CL, Webwe MB, eds. New York: Taylor & Francis Group. 2006; 1: 6-9.

Friedmann DP, Vick GL, Mishra V. Cellulite: A review with a focus on subcision. Clin Cosmet Investig Dermatol. 2017; 10: 17–23.

Hexsel D, Mazzuco R. Cellulite. (eds) Update in Cosmetic Dermatology. Springer-Verlag Berlin Heidelberg. 2013; 2: 21-32.

Tokarska Kamila, Tokarska Slawomir, Wozniacka Anna. Cellulite: a cosmetic or systemic issue? Contemporary views on the etiopathogenesis of cellulite. Adv Dermatology Allergol. 2018; XXXV (5):442-46.

Indriayani S, Putra IB, Jusuf NK. Relationship between plasma adiponectin levels and cellulite. Bali Medical Journal. 2022; 1 (11): 424-427.

Draelos ZD. Cellulite Pathophysiology. In: Cellulite Pathophysiology and Treatment. Goldman MP, Bacci PA. Second eds. New York: Taylor & Francis Group. 2019. p. 24–26.

Khan M, Bolotin D, Saedi N. Cellulite: Anatomy, Etiology, Treatment Indications. In: Body shaping skin, fat, cellulite. New York: Taylor & Francis Group. 2016; (12). p. 99-105.

Hexsel D, Dal'Forno TO, Mazzuco R. Definition, Clinical Aspects, Classifications, and Diagnostic Techniques. In: Cellulite Pathophysiology and Treatment. Goldman MP, Bacci PA. Second eds. New York: Taylor & Francis Group. 2019. p. 13–23.

Young VL, DiBernardo BE. Comparison of Cellulite Severity Scales and Imaging Methods. Aesthetic Surgery Journal. 2021; 41(6): 521–537.

Lima E, Lima M. Correcting Laxity and Cellulitis Using PCI. In: Percutaneous Collagen Induction with Microneedling. Switzerland: Springer Ltd. 2021; 173–184.

Amore R, Amuso D, Leonardi V, Sbarbati A, Conti G, Albini M, et al. Treatment of dimpling from cellulite. Plastic and Reconstructive Surgery. 2018; 6(5): 1–8.

Morihara K, Takai S, Takenaka H, Sakaguchi M, Okamoto Y, Morihara T, et al Cutaneous tissue angiotensineconverting enzyme may participate in pathologic scar formation in human skin. Journal of American Academy of Dermatology. 2006; 54 (2): 251-257.

Teckelings UM, Wollschla¨ger T, Peters J, Henz BM, Hermes B, Artuc M. Human skin: source of and target organ for angiotensin II. Experimental Dermatology. 2004; 13: 148-154.

Almeida M.C, Serrano C.S, Roldan J.R, Rejano J.J. Cellulite;s aetiology: a review. Journal of the European Academy of Dermatology and Venereology. Spain. 2012; 1-6.

Skurk T, Harmelen VV, Hauner H. Angiotensin II Stimulates the Release of Interleukin-6 and Interleukin-8 From Cultured Human Adipocytes by Activation of NF-kB. American Heart Association. 2004; 24: 1199-1203.

Verrecchia F, mauviel A. Transforming Growth Factor-b Signaling Through the Smad Pathway: Role in Extracellular Matrix Gene Expression and Regulation. The Society for Investigative Dermatology, Inc. 2002;118(2).

Friedmann DP, Vick GL, Mishra V. Cellulite: A review with a focus on subcision. Clin Cosmet Investig Dermatol. 2017; 10: 17–23.

Emanuele E, Bertina M, Geroldi D. A multilocus candidate approach identifies ACE and HIF1A as susceptibilty genes for cellulite. Journal European Academy of Dermatology and Venereology. 2010; 1-6.

Hexsel D, Hexsel CL, and Weber MB. Social Impact of Cellulite and Its Impact on Quality of Life. Cellulite Pathophysiology and treatment 2nd Edition. 2010;1-4.

Afonso JP, Tucunduva TC, Pinheiro MV, Bagatin E. Cellulite: a review. Surgical & Cosmetic Dermatology. 2010; 2 (3): 213–219.

Bass LS, Kaminer MS. Insights Into the Pathophysiology of Cellulite: A Review. Dermatologic Surgery. 2020; 46: 77–85.

Mirrashed F , Sharp JC , Krausel V, Morgan JM, Tomanek M. Pilot study of Dermal and Subcutaneous Fat Structures by MRI in Individuals that differ in Gender, BMI, and Cellulite Grading. Proc. Intl. Soc. Mag. Reson. Med. 2003; 11: 1

Lubis AF, Jusuf NK, Putra IB. Relationship between waist hip ratio index and photonumeric cellulite severity scale on cellulite. Bali Medical Journal. 2023; 12 (1): 1

Rossi AB, Vergnanini AL, Cellulite: a review. Journal of the European Academy of Dermatology and Venereology. 2000; 14: 251-262.

Uebel CO, Piccinini PS, Martinelli A, Aguiar DF, Matta RF. Cellulite: A Surgical Treatment Approach. Oxford University Press. 2018; 38 (10): 1099-1114.

Arisa E, Ortiz MD, Avram MM. The architecture of cellulite. In: Fat Removal: Invasive and Non-Invasive Body Contouring. Avram MM, eds. USA: John Wiley & Sons Ltd. 2015. p. 59–67.

Fovina A, Jusuf NK, Putra IB. Relationship between hypoxia inducible factor 1 alpha (HIF-1α) levels and cellulite. Bali Medical Journal. 2023; 12(2): 1724-1728.

Del Pino E, Rosado R, Auela A, Guzman G, Arguelles D. Effect of controlled volumetric tissue heating with radiofrequency on cellulite and the subcutaneous tissue of the buttocks and thighs. Journal of Drugs in Dermatology. 2006; 5 (8): 709-1.

Avram MM. Cellulite: a review of its physiology and treatment. Journal of Cosmetic and Laser Therapy. 2009; 6 (4): 181-185.

Fahim S, Montazer F , Tohidinik HR, Naraghi ZS , Abedini R, Nasimi M, et al. Serum and tissue angiotensin converting enzyme in patients with alopecia areata. Indian Journal of Dermatology, Venereology and Leprology. 2018; 1: 1.

Godoy JM, Godoy MF. Evaluation of the Prevalence of Concomitant Idiopathic Cyclic Edema and Cellulite. International Journal of Medical Sciences. 2011; 8 (6): 453–455.

Stavroulaki A, Pramantiotis G. Cellulite, smoking and angiotensin-converting enzyme (ACE) gene insertion⁄deletion polymorphism. Journal of the European Academy Dermatology and Venereology. 2011; 25(9):1116–1117.

Goossens GH, McQuaid SE, Dennis AL et al. Angiotensin II: a major regulator of subcutaneous adipose tissue blood flow in humans. J Physiol 2006; 571: 451–460.

Harris B. Selulit. Ibnu Sina Biomedika. 2018; 2(1): 104-115.

Dost T, Kafkas S , Gokalp F, Karul A , Birincioglu M. Effects of angiotensin converting enzyme inhibition on adiponectin levels and lipid profile in the ovariectomized aged rats. Journal of Pharmacology and Pharmacotherapeutics. 2014; 5(1): 1.
Share:

Z

Annisa Astari, Putra, I. B., & Jusuf, N. K. (2024). Relationship between Angiotensin Converting Enzyme (ACE) and Cellulite. Journal of Society Medicine, 3(3), 82–88. https://doi.org/10.47353/jsocmed.v3i3.133